A unique posterior segment manifestation of whipple disease.

Purpose: To report a novel posterior segment manifestation of Whipple disease.

Method: Single observational case study.

Results: The white crystalline deposit in the retina, choroiditis, and vitritis resolved with treatment of Whipple disease.

Whipple's disease-associated pulmonary hypertension with positive vasodilator response despite severe hemodynamic derangements.

Pulmonary hypertension (PH) associated with Whipple's disease (WD-PH) is extremely rare, and the underlying pathophysiological processes are incompletely understood. Alterations in hemodynamics can be severe, with right ventricular (RV) dysfunction being common. A case involving a 23-year-old man with WD-PH who exhibited a dramatic vasodilator response during right heart catheterization despite severely altered pulmonary hemodynamics and concomitant RV dysfunction is reported.