Botulinum toxin injections for the treatment of hip instability in the pediatric population with cerebral palsy: a systematic review.

The purpose of this review was to examine the effects of hip muscle botulinum toxin injections for the treatment of hip instability reported in studies of children with cerebral palsy. Searches in PubMed, CINAHL, and Web of Science were performed using the term hips combined with botulinum toxin and its various abbreviations and brand names. Reference lists and citations of the reviewed studies were also searched.

Left atrial shunting devices: why, what, how, and… when?

Left atrial (LA) hypertension is central in the pathophysiology of heart failure (HF) in general and of HF with preserved ejection fraction (HFpEF) in particular. Despite approved treatments, a number of HF patients continue experiencing disabling symptoms due to LA hypertension, causing pulmonary congestion, pulmonary hypertension, and right heart dysfunction, at rest and/or during exercise. LA decompression therapies, i.

Perspectives of Additive Manufacturing in 5.0 Industry.

Additive manufacturing is a technology that creates objects by adding successive layers of material. The 3D method is an alternative to subtractive production, in which production involves removing material from the initial solid. 3D printing requires the initial design of the manufactured object using computer design, for example, one of the following programs: CAD, 3DCrafter, Wings 3D, Cinema 3, Blender, 3ds Max, Autodesk Inventor, and others.

Systematic Ultrasound Screening for Lower Extremity Deep Vein Thrombosis in ICU Patients with Severe COVID-19: A Randomized Clinical Trial.

Background: Venous thromboembolism (VTE), whether pulmonary embolism (PE) or deep vein thrombosis (DVT), is common in patients with COVID-19. Recommendations on systematic screening in the intensive care unit (ICU) are lacking.

Research Question: Is there any clinical benefit of systematic screening for DVT in critically ill patients with severe COVID-19?

Study Design And Methods: Single-center randomized clinical trial (RCT) of COVID-19 cases admitted to the ICU.

Phone call for diabetic people: protocol for a pragmatic, type 1 effectiveness-implementation hybrid clinical trial.

Objective: To describe an implementation study protocol for an intervention based on educational guidelines focused on seven self-care behaviors, through phone calls to individuals with type 2 diabetes.

Method: We will conduct a hybrid type 1 effectiveness-implementation pragmatic randomized clinical trial, with 198 individuals with type 2 diabetes on insulin therapy, from the Glycemic Self-Monitoring Program of two Primary Health Care in the city of São Paulo and three in Campinas, located in the state of Sao Paulo. Patients will be allocated in a 1:1 ratio to either the intervention or control group.

Efficient Management of Asbestos Waste Through Utilization as Mineral Additives in Portland Cement Production.

This article presents research on the effectiveness of utilizing asbestos waste, particularly chrysotile asbestos, in the production of Portland cement. The study aimed to evaluate the feasibility of transforming asbestos cement (Eternit) through thermal treatment and its enrichment with mineral additives, enabling its integration into the clinker synthesis process. Differences in the physicochemical properties of types of cement produced from conventional raw materials and those manufactured using asbestos waste were analyzed.

Short-Term Changes in TNF-Alpha, IL-6 and Adiponectin Following Bariatric Surgery in Caucasian Obese Adults: An Observational Case-Control Study.

Overweight and obesity are well-known conditions that negatively impact the health and lifestyle of an individual. Bariatric surgery is one of the most efficient weight loss techniques. Besides the main effect on the bodyweight, improvement in the levels of inflammatory biomarkers, such as interleukin 6 (IL-6), tumor necrosis factor alpha (TNFalfa), and others, has been observed.

Surface Quality as a Factor Affecting the Functionality of Products Manufactured with Metal and 3D Printing Technologies.

Surface engineering is one of the most extensive industries. Virtually all areas of the economy benefit from the achievements of surface engineering. Surface quality affects the quality of finished products as well as the quality of manufactured parts.

Non-canonical amino acids for site-directed spin labeling of membrane proteins.

Membrane proteins remain challenging targets for conventional structural biology techniques because they need to reside within complex hydrophobic lipid environments to maintain proper structure and function. Magnetic resonance combined with site-directed spin labeling is an alternative method that provides atomic-level structural and dynamical information from effects introduced by an electron- or nuclear-based spin label. With the advent of bioorthogonal click chemistries and genetically engineered non-canonical amino acids (ncAAs), options for linking spin probes to biomolecules have substantially broadened outside the conventional cysteine-based labeling scheme.

Animal pollination shapes fruits market features, seeds functional traits and modulates their chemistry.

In this study, we experimentally addressed the impact of different pollination treatments on the morphological, reproductive and chemical traits of fruits and seeds of two crop species, the wild strawberry (Fragaria vesca L.) and cowpea (Vigna unguiculata (L.) Walp.

Survey of the POSNA Membership Reveals Variability in Use of Tibialis Anterior Tendon Transfer for Recurrent Clubfoot.

Purpose: The aim of this project was to survey members of the Pediatric Orthopaedic Society of North America (POSNA) regarding the use of tibialis anterior tendon transfer (TATT) in the management of recurrent clubfoot with dynamic supination and no deformity. We aimed to assess which techniques for TATT are most utilized by pediatric orthopedists. As there has been no general consensus in the literature regarding best methods, we hypothesized that treatment methods would vary widely among POSNA members.

Accumulation of Environmental Radioactivity on the Surface of a High Arctic Ice Cap (Flade Isblink, NE Greenland).

Under climatic warming, glaciers are becoming a secondary source of atmospheric contaminants originally released into the environment decades ago. This phenomenon has been well-documented for glaciers near emission sources. However, less is known about polar ice sheets and ice caps.

Glacier mice as a temporary sink for fallout radionuclides and heavy metals on the Norwegian glacier Austerdalsbreen.

Glacier mice are peculiar rolling or stationary moss balls found on the surface of some glaciers. They may harbour an ecological habitat for cold-adapted invertebrates and microorganisms, but little is known about their potential to accumulate and disseminate harmful elements and substances. In this study, we investigate the presence of fallout radionuclides (Cs, Pu, Pu, Pu, Pb) and heavy metals (Pb, As, Hg, Cd) in glacier mice and compare the results to bryophytes from adjacent glacier ecosystems.

A novel MT-ATP6 variant associated with complicated ataxia in two unrelated Italian patients: case report and functional studies.

Background: MT-ATP6 is a mitochondrial gene which encodes for the intramembrane subunit 6 (or A) of the mitochondrial ATP synthase, also known asl complex V, which is involved in the last step of oxidative phosphorylation to produce cellular ATP through aerobic metabolism. Although classically associated with the NARP syndrome, recent evidence highlights an important role of MT-ATP6 pathogenic variants in complicated adult-onset ataxias.

Methods: We describe two unrelated patients with adult-onset cerebellar ataxia associated with severe optic atrophy and mild cognitive impairment.

Hydrological variability of middle European peatland during the Holocene, inferred from subfossil bog pine and bog oak dendrochronology and high-resolution peat multiproxy analysis of the Budwity peatland (northern Poland).

Subfossil pine and oak tree trunks were excavated during exploitation of the Budwity peatland in Northern Poland. Based on dendrochronological analysis, the woodland successions in peatland were reconstructed and correlated with moisture dynamics of the peatland ecosystem inferred from the high-resolution multi-proxy analysis of the peatland deposits. From the results of dendrochronological analysis and the C wiggle matching methods, four floating pine chronologies (5882-5595; 5250-5089; 3702-3546; and 2222-1979 mod.

Endocrine, auxological and metabolic profile in children and adolescents with Down syndrome: from infancy to the first steps into adult life.

Down syndrome (DS) is the most common chromosomal disorder worldwide. Along with intellectual disability, endocrine disorders represent a remarkable share of the morbidities experienced by children, adolescents and young adults with DS. Auxological parameters are plotted on syndrome-specific charts, as growth rates are reduced compared to healthy age- and gender-matched peers.

Reliability of the Clinical Measurement of Joint Motion and Muscle Length in the Upper and Lower Extremities of Children with Cerebral Palsy: A Systematic Review.

Reliability of joint motion and muscle length measurement in children with cerebral palsy was examined. Twenty-one studies of intraobserver and/or interobserver reliability were reviewed: joint motion of upper extremities in four and lower extremities in 13; muscle length of upper extremities in one and lower extremities in 15. Intraclass correlation coefficients for goniometric interobserver reliability varied widely for joint motion (range 0.

TP53INP2-dependent activation of muscle autophagy ameliorates sarcopenia and promotes healthy aging.

Sarcopenia is a major contributor to disability in older adults, and thus, it is key to elucidate the mechanisms underlying its development. Increasing evidence suggests that impaired macroautophagy/autophagy contributes to the development of sarcopenia. However, the mechanisms leading to reduced autophagy during aging remain largely unexplored, and whether autophagy activation protects from sarcopenia has not been fully addressed.

Late Complications after Laparoscopic Longitudinal Gastrectomy - Case Report.

Introduction: Bariatric surgery is now widely regarded as the most effective treatment for morbid obesity. It aims to enhance patients' health by achieving long-lasting weight loss, reducing associated comorbidities, and improving their quality of life.

Case Report: The case involves a 51-year-old female patient who underwent sleeve gastrectomy eight years ago to address morbid obesity (Body Mass Index (BMI) = 43).