Publications by authors named "Sakurako Suma"
Background: Primary central nervous system lymphoma (PCNSL) is a rare lymphoid malignancy. Systemic profiling of the PCNSL tumor microenvironment (TME) was previously conducted through gene expression analysis. We investigated the prognostic impact of TME on survival to establish novel prognostic biomarkers in PCNSL patients.
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- Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare type of T-cell lymphoma that primarily affects the skin and has a high five-year survival rate of over 80%.
- A study involving whole-exome sequencing of 60 samples from 36 SPTCL patients identified 138 mutations in skin tumors and recurring HAVCR2 germline mutations in many patients, particularly in Japanese individuals.
- Despite treatment with multiple chemotherapy agents, some patients showed only partial responses, but their conditions remained stable with further treatments, highlighting the importance of long-term monitoring due to potential complications.
Article Synopsis
- T follicular helper cell lymphomas (TFHLs) show T-like properties and significant immune cell infiltration, but understanding of their tumor-cell diversity and immune profiles is limited.
- A single-cell transcriptomic analysis revealed five distinct subclusters of tumor cells with varying T marker expressions, indicating clonal evolution driven by genetic changes.
- Increased exhausted CD8 T cells and unique immune evasion tactics from various immune cell types contribute to a complex immunosuppressive environment, suggesting that this heterogeneity may be linked to treatment resistance in TFHL.
Angioimmunoblastic T-cell lymphoma (AITL) is proposed to be initiated by age-related clonal hematopoiesis (ACH) with TET2 mutations, whereas the G17V RHOA mutation in immature cells with TET2 mutations promotes the development of T follicular helper (TFH)-like tumor cells. Here, we investigated the mechanism by which TET2-mutant immune cells enable AITL development using mouse models and human samples. Among the 2 mouse models, mice lacking Tet2 in all the blood cells (Mx-Cre × Tet2flox/flox × G17V RHOA transgenic mice) spontaneously developed AITL for approximately up to a year, while mice lacking Tet2 only in the T cells (Cd4-Cre × Tet2flox/flox × G17V RHOA transgenic mice) did not.
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- Angioimmunoblastic T-cell lymphoma (AITL) is a challenging type of T-cell lymphoma characterized by the specific p.Gly17Val RHOA mutation.
- A patient experienced worsening health due to cardiac issues after receiving autologous transplantation for AITL, leading to a diagnosis of cardiac tamponade related to AITL recurrence.
- The case highlights the potential for precision medicine, suggesting that monitoring the p.Gly17Val RHOA mutation can improve AITL management.
Objective Graft failure (GF) is a life-threatening complication of hematopoietic stem cell transplantation (HSCT). A standardized conditioning regimen and an appropriate graft source of salvage HSCT for GF have not yet been established. Some case series have shown good hematopoietic recoveries after salvage HSCT using a short-term reduced-intensity preparative regimen consisting of fludarabine (30-90 mg/m), cyclophosphamide (2 g/m), and total-body irradiation (2 Gy).
View Article and Find Full Text PDFActivating mutations in the Vav guanine nucleotide exchange factor 1 (VAV1) gene are reported in various subtypes of mature T-cell neoplasms (TCNs). However, oncogenic activities associated with VAV1 mutations in TCNs remain unclear. To define them, we established transgenic mice expressing VAV1 mutants cloned from human TCNs.
View Article and Find Full Text PDFChronic active Epstein-Barr virus infection (CAEBV) is critical owing to lethal complications such as hemophagocytic lymphohistiocytosis (HLH), multiple organ failure, and malignant lymphoma. Here we present two cases of CAEBV who developed rapid and life-threatening disease progression after cytotoxic chemotherapy. Case 1: In a 34-year-old male, CAEBV recurred after 4-month remission obtained by initial therapy with etoposide, cyclosporine, and prednisolone.
View Article and Find Full Text PDFA 78-year-old man was referred to Tsukuba University Hospital for right hydronephrosis. He had undergone ureteroscopy and ureteral stenting in another hospital, but no tumor was revealed in renal pelvis and ureter. The urinary cytology was negative.
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- - Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare type of blood cancer, and its development process is not fully understood.
- - In a study, researchers analyzed gene mutations in tumor and non-tumor cells from a BPDCN patient and identified specific mutations that differed between these cell types.
- - The findings suggest that BPDCN may develop from clonal hematopoiesis, where certain mutations appear in normal blood cells before leading to the formation of the tumor.