Publications by authors named "Sakurako Kunieda"

A parasitic leiomyoma has no connection with the uterus itself and obtains its blood supply from the surrounding tissues. A parasitic leiomyoma that develops iatrogenically is called an iatrogenic parasitic leiomyoma. Clinical reports on parasitic leiomyoma are common in gynecology but not in plastic surgery.

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Human adipose-derived stem cells (hASCs) play important roles in regenerative medicine and tissue engineering. However, their clinical applications are limited because of their instability during cell culture. Platelet lysates (PLTs) contain large amounts of growth factors that are useful for manufacturing cellular products.

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Article Synopsis
  • Stem cell therapy, particularly human adipose-derived stem cells (hASCs), shows potential in regenerative medicine and is easily harvested for applications in plastic surgery, including fat grafting and wound healing.
  • Platelet-rich plasma (PRP), rich in growth factors like PDGF, enhances hASC proliferation, adhesion, and migration by activating key signaling pathways such as AKT and ERK1/2.
  • PRP treatment proves to be more effective than PDGF alone in promoting hASC movement and adhesion, leading to improved cell growth and therapeutic outcomes.
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Degloving, a skin and subcutis avulsion, is a severe traumatic injury sometimes caused by rolling wheels or machines. Although avulsed flaps are often readapted to its original site, most of these tissues become necrotic. Due to the extensive skin and soft tissue deficiency caused by necrosis, treatment becomes difficult.

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