Publications by authors named "Sakurako Katsuura-Kamano"

The prospective cohort study in a large Japanese population suggested that metabolic phenotypes are important risk factors for total and some site-specific cancers in Japanese adults. Moreover, the risk of each site-specific cancer may differ according to metabolic phenotypes.

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  • - This study investigated the link between small fish consumption and mortality rates, focusing on a cohort of 80,802 participants in Japan aged 35-69.
  • - Results showed that higher intake of small fish significantly lowered the risk of all-cause and cancer-related deaths in females, while no notable relationship was found for males.
  • - The findings suggest that incorporating small fish into the diet may be beneficial for reducing mortality risks, particularly for women.
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  • This study addresses the genetic factors affecting kidney function in East Asians, particularly the Japanese, highlighting the need for more extensive GWAS with larger sample sizes due to limited previous research.* -
  • Utilizing data from around 200,000 Japanese participants, the authors conducted a meta-analysis that revealed 110 loci linked to estimated glomerular filtration rate (eGFR) and 112 loci associated with serum creatinine (SCr).* -
  • The findings include a novel variant (CD36 rs146148222) and suggest that understanding these genetic associations can lead to personalized strategies for preventing kidney diseases in the future.*
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  • A study investigated the genetic factors influencing alcohol consumption in 175,672 Japanese individuals, focusing on a specific genetic variant (rs671) associated with drinking behavior.
  • The analysis found significant genetic interactions, identifying three key genetic locations in individuals with one variant (wild-type homozygotes) and six in those with two variants (heterozygotes), with some linked to esophageal cancer risk.
  • The research highlights how genetic makeup can shape alcohol consumption patterns and potentially increase the risk of alcohol-related diseases in different ancestral groups.
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  • The GWAS focused on identifying genetic loci linked to folate metabolites such as homocysteine, folic acid, and vitamin B levels in a Japanese cohort.
  • The study analyzed data from 2,263 participants in the J-MICC Study and replicated findings in 573 participants from the Yakumo Study, highlighting significant loci on chromosomes 1, 11, and 16.
  • Results indicated notable gene-environment interactions, particularly involving the MTHFR gene and factors like alcohol consumption and physical activity, suggesting implications for personalized cardiovascular disease prevention.
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Background: Previous cohort studies have yielded contradictory findings regarding the associations of dietary carbohydrate and fat intakes with risks of mortality.

Objectives: We examined long-term associations of carbohydrate and fat intakes with mortality.

Methods: In this cohort study, 34,893 men and 46,440 women aged 35-69 y (mean body mass index of 23.

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The association between kidney function and cancer incidence is inconsistent among previous reports, and data on the Japanese population are lacking. It is unknown whether kidney function modifies the cancer risk of other factors. We aimed to evaluate the association of estimated glomerular filtration rate (eGFR) with cancer incidence and mortality in 55 242 participants (median age, 57 years; 55% women) from the Japan Multi-Institutional Collaborative Cohort Study.

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Observational studies suggest that abnormal glucose metabolism and insulin resistance contribute to colorectal cancer; however, the causal association remains unknown, particularly in Asian populations. A two-sample Mendelian randomisation analysis was performed to determine the causal association between genetic variants associated with elevated fasting glucose, haemoglobin A1c (HbA1c), and fasting C-peptide and colorectal cancer risk. In the single nucleotide polymorphism (SNP)-exposure analysis, we meta-analysed study-level genome-wide associations of fasting glucose (~ 17,289 individuals), HbA1c (~ 52,802 individuals), and fasting C-peptide (1,666 individuals) levels from the Japanese Consortium of Genetic Epidemiology studies.

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  • The study investigates genetic factors influencing hemoglobin A1c (HbA1c) and blood glucose levels in a non-diabetic Japanese population, using a two-phase genome-wide association study (GWAS).
  • The research involved 4911 initial participants and replicated findings with a larger sample size from the Tohoku Medical Megabank project, adjusting for variables such as age, sex, BMI, and smoking.
  • Results showed a specific genetic variant (rs2299620) linked to HbA1c levels, with its impact varying according to BMI categories, whereas no variants for blood glucose levels were successfully replicated.
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  • - The study examines how gene-lifestyle interactions influence body mass index (BMI) and emphasizes the need for personalized nutrition in obesity treatment strategies, as current evidence is limited.
  • - Using data from over 12,000 participants, researchers found a significant correlation (r = 0.13) between a multi-locus genetic risk score (GRS) and BMI, highlighting the impact of genetic factors on obesity.
  • - Results showed interactions between GRS and certain dietary intakes, such as saturated fatty acids and n-3 polyunsaturated fatty acids, suggesting that personalized dietary recommendations based on genetic predisposition could improve obesity prevention and treatment.
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Background And Aims: To date, the relationship between coffee consumption and metabolic phenotypes has hardly been investigated and remains controversial. Therefore, the aim of this cross-sectional study is to examine the associations between coffee consumption and metabolic phenotypes in a Japanese population.

Methods And Results: We analyzed the data of 26,363 subjects (aged 35-69 years) in the baseline survey of the Japan Multi-Institutional Collaborative Cohort Study.

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Background: Although many observational studies have demonstrated significant relationships between obesity and cardiometabolic traits, the causality of these relationships in East Asians remains to be elucidated.

Methods: We conducted individual-level Mendelian randomization (MR) analyses targeting 14,083 participants in the Japan Multi-Institutional Collaborative Cohort Study and two-sample MR analyses using summary statistics based on genome-wide association study data from 173,430 Japanese. Using 83 body mass index (BMI)-related loci, genetic risk scores (GRS) for BMI were calculated, and the effects of BMI on cardiometabolic traits were examined for individual-level MR analyses using the two-stage least squares estimator method.

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Objectives: Previous studies using objective parameters have shown that irregular sleep is associated with the disease incidence, progression, or mortality. This study aimed to determine the association between subjective sleep duration and sleep regularity, with mortality in a large population.

Methods: Participants were from the Japan Multi-Institutional Collaborative Cohort study.

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  • Genetic factors influence how individuals experience pain, prompting researchers to conduct a genome-wide association study (GWAS) focused on patients with cancer pain and the general population.
  • The study combined two cohorts: an exploratory group assessed using pain intensity ratings and opioid dosages, and a confirmatory group that evaluated habitual use of nonsteroidal anti-inflammatory drugs.
  • A novel single-nucleotide polymorphism (SNP) associated with pain was identified on chromosome 7, linked to the gene for pleiotrophin, which showed significant correlations with analgesic use, although its minor allele affected pain in the opposite way than expected.
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Purpose: The association between metabolic syndrome (MetS) and the risk of death from cancer is still a controversial issue. The purpose of this study was to examine the associations of MetS and metabolically unhealthy obesity (MUHO) with cancer mortality in a Japanese population.

Methods: We used data from the Japan Multi-Institutional Collaborative Cohort Study.

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Background/objectives: Low-carbohydrate diets (LCD) are useful for weight reduction, and 50-55% carbohydrate consumption is associated with minimal risk. Genetic differences were related to nutritional consumption, food preferences, and dietary patterns, but whether particular genetic differences in individuals influence LCD adherence is unknown.

Subjects/methods: We conducted a GWAS on adherence to LCD utilizing 14,076 participants from the Japan Multi-Institutional Collaborative Cohort study.

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Objective: The aim of the present study was to investigate the associations between breastfeeding and the prevalence of metabolic syndrome in community-dwelling parous women and to clarify whether the associations depend on age.

Methods: The present cross-sectional study included 11,118 women, aged 35-69 years. Participants' longest breastfeeding duration for one child and their number of breastfed children were assessed using a self-administered questionnaire, and their total breastfeeding duration was approximated as a product of the number of breastfed children and the longest breastfeeding duration.

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Previous studies have reported that the number of pregnancies and childbirths affected the risk of cardiovascular diseases (CVDs). However, the influence of reproductive history on hypertension and obesity, which are important risk factors for CVDs, is still unclear. Moreover, this association may vary depending on menopausal status.

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  • Understanding psychosocial stress and coping behaviors is crucial for addressing risk factors associated with chronic kidney disease (CKD) and its progression to end-stage renal disease.
  • A study of nearly 70,000 middle-aged and older Japanese individuals revealed that perceived stress negatively correlated with kidney function (eGFR) specifically in men, with the effect less pronounced after accounting for hypertension and diabetes.
  • Additionally, certain coping strategies, like problem-solving for men and positive reappraisal for women, were unexpectedly linked to decreased kidney function, suggesting the need for further investigation into how these factors interact.
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Introduction: Healthy diet and physical activity (PA) are essential for preventing type 2 diabetes, particularly, a combination of diet and PA. However, reports on interaction between PA and diet, especially from large epidemiological studies, are limited. We investigated the effect of interaction between PA and macronutrient intake on hemoglobin A1c (HbA1c) levels in the general population.

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The purpose of the study was to investigate sex-specific associations of skipping breakfast and short sleep duration with metabolic syndrome (MetS) and their interaction. We analyzed baseline data of 14,907 men and 14,873 women aged 35-69 years, who participated in the Japan Multi-Institutional Collaborative Cohort Study from 2005. MetS was diagnosed using a modification of the National Cholesterol Education Program Adult Treatment Panel III revised definition (NCEP-R 2005), using body mass index instead of waist circumference.

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Recent genome-wide association studies (GWAS) on the dietary habits of the Japanese population have shown that an effect rs671 allele was inversely associated with fish consumption, whereas it was directly associated with coffee consumption. Although meat is a major source of protein and fat in the diet, whether genetic factors that influence meat-eating habits in healthy populations are unknown. This study aimed to conduct a GWAS to find genetic variations that affect meat consumption in a Japanese population.

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Background: Little is known about whether insufficient moderate-to-vigorous physical activity (MVPA) and longer sedentary behavior (SB) are independently associated with estimated glomerular filtration rate (eGFR) and chronic kidney disease (CKD), whether they interact with known risk factors for CKD, and the effect of replacing sedentary time with an equivalent duration of physical activity on kidney function.

Methods: We examined the cross-sectional association of MVPA and SB with eGFR and CKD in 66,603 Japanese cohort study in 14 areas from 2004 to 2013. MVPA and SB were estimated using a self-reported questionnaire, and CKD was defined as eGFR <60 mL/min/1.

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Background: Stress coping strategies are related to health outcomes. However, there is no clear evidence for sex differences between stress-coping strategies and mortality. We investigated the relationship between all-cause mortality and stress-coping strategies, focusing on sex differences among Japanese adults.

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