Publications by authors named "Sakurako Emoto"
Background: In the six Southeast Asian countries that make up the Greater Mekong Subregion, has developed resistance to derivatives of artemisinin, the main component of first-line treatments for malaria. Clinical resistance to artemisinin monotherapy in other global regions, including Africa, would be problematic.
Methods: In this longitudinal study conducted in Northern Uganda, we treated patients who had infection with intravenous artesunate (a water-soluble artemisinin derivative) and estimated the parasite clearance half-life.
In Uganda, artemether-lumefantrine was introduced as an artemisinin-based combination therapy (ACT) for malaria in 2006. We have previously reported a moderate decrease in ex vivo efficacy of lumefantrine in Northern Uganda, where we also detected ex vivo artemisinin-resistant Plasmodium falciparum. Therefore, it is necessary to search for candidate partner alternatives for ACT.
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- - The Chinese government enforced lockdowns in Hubei Province due to COVID-19, prompting the National Center for Global Health and Medicine (NCGM) to coordinate evacuation charter flights for Japanese citizens, successfully handling the majority of returnees (95.7%).
- - A total of five charter flights were organized, involving 107 doctors, 115 nurses, and other support staff, who implemented strict health precautions including airborne and contact precautions to minimize infection risk during the evacuation.
- - After the triage at NCGM, 48 individuals were hospitalized, with a higher COVID-19 positivity rate (8.3%) among those triaged compared to others, emphasizing the need for a structured response for future similar situations.