Publications by authors named "Sakura Higashida"
Background: Although a new potassium-competitive acid blocker (P-CAB) vonoprazan has been developed in Japan, no data are available regarding long-term vonoprazan or vonoprazan and acotiamide combination treatment in patients with functional dyspepsia (FD).
Methodology: A total of 73 consecutive patients with FD diagnosed according to the Rome III classification were enrolled. Forty-two patients with FD were treated with vonoprazan monotherapy and thirty-one patients with FD were treated with vonoprazan and acotiamide combination therapy for 24 weeks.
Article Synopsis
- - The study aimed to investigate differences in clinical characteristics and pancreatic enzyme abnormalities between patients with functional dyspepsia (FD) alone and those with FD overlapping with irritable bowel syndrome (IBS).
- - Results showed that patients with FD-IBS overlap reported worse symptoms after eating high-fat meals, even though pancreatic enzyme abnormalities were more prevalent in FD alone patients.
- - The presence of elevated levels of protease-activated receptor 2 (PAR2) in degranulated eosinophils in the duodenum was found to be significantly higher in the FD-IBS overlap group, suggesting a link to the condition's pathophysiology.