Construction of Methotrexate-Loaded BiS Coated with Fe/Mn-Bimetallic Doped ZIF-8 Nanocomposites for Cancer Treatment Through the Synergistic Effects of Photothermal/Chemodynamic/Chemotherapy.

A combination of therapeutic modalities in a single nanostructure is crucial for a successful cancer treatment. Synergistic photothermal therapy (PTT) can enhance the effects of chemodynamic therapy (CDT) and chemotherapy, which could intensify the therapeutic efficacy to induce cancer cell apoptosis. In this study, Fe and Mn on a zeolitic imidazolate framework (ZIF-8) (Fe/Mn-ZIF-8; FMZ) were synthesized through ion deposition.

Combinatorial Effects of 5-Fluorouracil and Menadione on Wnt/β-Catenin Pathway in Human Colorectal Cancer Cells.

The incidence and mortality rates of colorectal cancer (CRC) are alarmingly high, and the scientific community is consistently engaged in developing newer therapeutic options for cancer cure or prevention. The fluoropyrimidine drug, 5-fluorouracil (5FU), remains the first line of treatment against CRC; nevertheless, relapses frequently occur since the cells gain resistance over time through various mechanisms. Studies have highlighted the significance of combinatorial treatment of a Wnt signaling inhibitor and 5FU as a better treatment strategy to overcome 5FU resistance.

Schottky Junction-Driven Photocatalytic Effect in Boron-Doped Diamond-Graphene Core-Shell Nanoarchitectures: An sp/sp Framework for Environmental Remediation.

Self-formation of boron-doped diamond (BDD)-multilayer graphene (MLG) core-shell nanowalls (BDGNWs) via microwave plasma-enhanced chemical vapor deposition is systematically investigated. Here, the incorporation of nitrogen brings out the origin of MLG shells encapsulating the diamond core, resulting in unique sp/sp hybridized frameworks. The evolution mechanism of the nanowall-like morphology with the BDD-MLG core-shell composition is elucidated through a variety of spectroscopic studies.

Hardware optimization for effective switching power reduction during data compression in GOLOMB rice coding.

Loss-less data compression becomes the need of the hour for effective data compression and computation in VLSI test vector generation and testing in addition to hardware AI/ML computations. Golomb code is one of the effective technique for lossless data compression and it becomes valid only when the divisor can be expressed as power of two. This work aims to increase compression ratio by further encoding the unary part of the Golomb Rice (GR) code so as to decrease the amount of bits used, it mainly focuses on optimizing the hardware for encoding side.

Hydrothermally Grown Globosa-like TiO Nanostructures for Effective Photocatalytic Dye Degradation and LPG Sensing.

The rapid expansion of industrial activities has resulted in severe environmental pollution manifested by organic dyes discharged from the food, textile, and leather industries, as well as hazardous gas emissions from various industrial processes. Titanium dioxide (TiO)-nanostructured materials have emerged as promising candidates for effective photocatalytic dye degradation and gas sensing applications owing to their unique physicochemical properties. This study investigates the development of a photocatalyst and a liquefied petroleum gas (LPG) sensor using hydrothermally synthesized globosa-like TiO nanostructures (GTNs).

Facile synthesis of tantalum decorated on iron selenide with nitrogen-doped graphene hybrid for the sensitive detection of trolox in berries: Density functional theory interpretation.

This work presents a hydrothermal method followed by a sonochemical treatment for synthesizing tantalum decorated on iron selenide (Ta/FeSe) integrated with nitrogen-doped graphene (NGR) as a susceptible electrode material for detecting trolox (TRX) in berries samples. The surface morphology, structural characterizations, and electrochemical performances of the synthesized Ta/FeSe/NGR composite were analyzed via spectrophotometric and voltammetry techniques. The GCE modified with Ta/FeSe/NGR demonstrated an impressive linear range of 0.

Dual Z-scheme heterojunction CeSnO/AgPO/V@g-CN for increased photocatalytic degradation of the food additive tartrazine, in the presence of persulfate: Kinetics, toxicity, and density functional theory studies.

This study involved the synthesis of a CeSnO/AgPO/V@g-CN composite through hydrothermal methods, followed by mechanical grinding. The resulting heterojunction exhibited improved catalytic activity under visible light by effectively separating electrons and holes (e/h). The degradation of Tartrazine (TTZ) reached 93.

A CeMgMoO double perovskite decorated on a functionalized carbon nanofiber nanocomposite for quantification of ciprofloxacin in milk and honey samples: Density functional theory interpretation.

In this study, a novel CeMgMoO/CNFs (cerium magnesium molybdite double perovskite decorated on carbon nanofibers) nanocomposite was developed for selective and ultra-sensitive detection of ciprofloxacin (CFX). Physical characterization and analytical techniques were used to explore the morphology, structure, and electrocatalytic characteristics of the CeMgMoO/CNFs nanocomposite. The sensor has a wide linear range (0.

Near-infrared-driven upconversion nanoparticles with photocatalysts through water-splitting towards cancer treatment.

Water splitting is promising, especially for energy and environmental applications; however, there are limited studies on the link between water splitting and cancer treatment. Upconversion nanoparticles (UCNPs) can be used to convert near-infrared (NIR) light to ultraviolet (UV) or visible (Vis) light and have great potential for biomedical applications because of their profound penetration ability, theranostic approaches, low self-fluorescence background, reduced damage to biological tissue, and low toxicity. UCNPs with photocatalytic materials can enhance the photocatalytic activities that generate a shorter wavelength to increase the tissue penetration depth in the biological microenvironment under NIR light irradiation.

Gold nanoparticles decorated on MOF derived CuZn hollow porous carbon nanocubes for magnetic resonance imaging guided tumor microenvironment-mediated synergistic chemodynamic and photothermal therapy.

Combining chemodynamic therapy (CDT) with photothermal therapy (PTT) has developed as a promising approach for cancer treatment, as it enhances therapeutic efficiency through redox reactions and external laser induction. In this study, we designed metal organic framework (MOF) -derived CuZn/HPCNC through a carbonization process and decorated them with gold nanoparticles (Au@CuZn/HPCNC). The resulting nanoparticles were employed as a photothermal agent and Fenton catalyst.

A sensitive sandwich-type electrochemical immunosensor using nitrogen-doped graphene/metal-organic framework-derived CuMnCoO and Au/MXene for the detection of breast cancer biomarker.

In terms of cancer-related deaths among women, breast cancer (BC) is the most common. Clinically, human epidermal growth receptor 2 (HER2) is one of the most commonly used diagnostic biomarkers for facilitating BC cell proliferation and malignant growth. In this study, a disposable gold electrode (DGE) modified with gold nanoparticle-decorated TiCT (Au/MXene) was utilized as a sensing platform to immobilize the capturing antibody (Ab/Au/MXene).

A Metal-Free Triazacoronene-Based Bimodal VOC Sensor.

Developing suitable sensors for selective and sensitive detection of volatile organic compounds (VOCs) is crucial for monitoring indoor and outdoor air quality. VOCs are very harmful to our health upon inhalation or contact. Bimodal sensor materials with more than one transduction capability (optical and electrical) offer the ability to extract complementary information from the individual analyte, thus improving detection accuracy and performance.

Composite fault reconstruction and fault-tolerant control design for cyber-physical systems: An interval type-2 fuzzy approach.

This article scrutinizes the stabilization and fault reconstruction issues for interval type-2 fuzzy-based cyber-physical systems with actuator faults, deception attacks and external disturbances. The primary objective of this research is to formulate the learning observer system with the interval type-2 fuzzy technique that reconstructs the actuator faults as well as the immeasurable states of the addressed fuzzy based model. Further, the information of reconstructed actuator faults is incorporated in the developed controller with the imperfect premise variables for ensuring the stabilization of the system under consideration.

Stabilization of Periodic Piecewise Time-Varying Systems With Time-Varying Delay Under Multiple Cyber Attacks: An Augmented Lyapunov Functional Approach.

This article investigates the asymptotic stabilization of periodic piecewise time-varying systems with time-varying delay under various cyber attacks, particularly deception and acrlong DoS attacks. The addressed system is reformed into a number of time-varying subsystems based on the time interval for each period. Following that, a state-feedback controller with periodic time-varying gain parameters is developed to solve the stabilization problem.

2D/2D heterostructure Ni-Fe LDH/black phosphorus nanosheets with AuNP for noxious substance diphenylamine detection in food samples.

In this study, gold nanoparticles decorated on nickel-iron layered double hydroxide with black phosphorus nanosheets (AuNP/Ni-Fe LDH/BPNSs) composite were prepared using a stirring method. Analyte tracing is required for developing viable sensors. The AuNP/Ni-Fe LDH/BPNSs composite exhibited a large specific surface area, high conductivity, high electrocatalytic activity, and rapid electron transfer.

Observer-based state estimation for discrete-time semi-Markovian jump neural networks with round-robin protocol against cyber attacks.

This paper investigates an observer-based state estimation issue for discrete-time semi-Markovian jump neural networks with Round-Robin protocol and cyber attacks. In order to avoid the network congestion and save the communication resources, the Round-Robin protocol is used to schedule the data transmissions over the networks. Specifically, the cyber attacks are modeled as a set of random variables satisfying the Bernoulli distribution.

Highly responsive and sensitive non-enzymatic electrochemical sensor for the detection of β-NADH in food, environmental and biological samples using AuNP on polydopamine/titanium carbide composite.

In this study, a polydopamine/titanium carbide adorned with gold nanoparticles (Au@PDA/TiC) composite was prepared by a simple stirring technique and it was used for the dual-technique detection of β-Nicotinamide adenine dinucleotide (NADH). The Au@PDA/TiC-modified glassy carbon electrode (GCE) oxidized NADH at a very low oxidation potential of approximately 0.60 V vs Ag/AgCl in pH = 7.

Innate Immune Response Assessment in L. upon Experimental Administration with Bio-Encapsulated Bacterin.

The present study aimed to analyze the enhancement of innate immune responses in juvenile-stage common carp ( L.), upon the administration of heat-killed at a dosage of 1 × 10 CFU ml through bio-encapsulation in the aquatic crustacean, . This work emphasizes the modulation of innate immune response when administered with the bio-encapsulated heat-killed antigen that acts as an inactivated vaccine against Motile Aeromonas Septicemia disease.

Fixed Time-Point Analysis Reveals Repetitive Mild Traumatic Brain Injury Effects on Resting State Functional Magnetic Resonance Imaging Connectivity and Neuro-Spatial Protein Profiles.

Repetitive mild traumatic brain injuries (rmTBIs) are serious trauma events responsible for the development of numerous neurodegenerative disorders. A major challenge in developing diagnostics and treatments for the consequences of rmTBI is the fundamental knowledge gaps of the molecular mechanisms responsible for neurodegeneration. It is both critical and urgent to understand the neuropathological and functional consequences of rmTBI to develop effective therapeutic strategies.

Polydopamine-Coated Cu-BTC Nanowires for Effective Magnetic Resonance Imaging and Photothermal Therapy.

Herein, we present a one-pot hydrothermal approach for synthesizing metal-organic framework-derived copper (II) benzene-1,3,5-tricarboxylate (Cu-BTC) nanowires (NWs) using dopamine as the reducing agent and precursor for a polydopamine (PDA) surface coating formation. In addition, PDA can act as a PTT agent and enhance NIR absorption, producing photothermal effects on cancer cells. These NWs displayed a photothermal conversion efficiency of 13.

Disturbance rejection for multi-weighted complex dynamical networks with actuator saturation and deception attacks via hybrid-triggered mechanism.

In this work, we address hybrid-driven-based robust synchronization problem for multi-weighted complex dynamical networks with actuator saturation and deception attacks. The hybrid-triggered mechanism, which combines a switch between the event-triggered scheme and the time-triggered scheme, is often used to reduce the data transmission and the alleviate network burden. Further, the equivalent-input-disturbance technique is applied to eliminate the unknown disturbance effect of the addressed system.

Nursing Student's Satisfaction With Virtual Learning During COVID-19 Pandemic in India.

Introduction: The COVID-19 pandemic significantly impacted the world in 2020. Every country adopted quarantine measures to prevent the transmission of the coronavirus infection. These measures resulted in dramatic changes in the daily lives of most people.