Double-Duty Carers' Health and Wellbeing during COVID-19: Exploring the Role of Mobility of the Care Economy in Southern Ontario, Canada.

Double-Duty Carers (DDCs) refer to people who work in the healthcare industry while also providing unpaid care to relatives, friends, or neighbours. The expectations placed on DDCs is expected to grow, and these employees already experience a high caring burden. As such it is important to understand how best to support their health and wellbeing.

Light-Induced, Structural Matrix Guided Stepwise Spin-State Switching in 3d-5d Molecular Assembly.

A new iron(II) molecular complex {[W(CN)][Fe(bik*)]}BF·7HO·1.5CHOH (.7HO·1.

Bacteriophages in nature: recent advances in research tools and diverse environmental and biotechnological applications.

Bacteriophages infect and replicate within bacteria and play a key role in the environment, particularly in microbial ecosystems and bacterial population dynamics. The increasing recognition of their significance stems from their wide array of environmental and biotechnological uses, which encompass the mounting issue of antimicrobial resistance (AMR). Beyond their therapeutic potential in combating antibiotic-resistant infections, bacteriophages also find vast applications such as water quality monitoring, bioremediation, and nutrient cycling within environmental sciences.

Bis-[cyclic(alkyl)(amino)carbene]-derived diradicals.

Crystalline polymeric structures of -1,4-cyclohexylene bridged -tethered bis-CAACs in the form of their LiOTf adducts were synthesized and isolated. These were further used as building blocks for the synthesis of crystalline (amino)(carboxy)-based diradicals. The triplet diradical character of these compounds was unambiguously confirmed by the presence of a half-field signal in their EPR spectra.

Stimuli-responsive magnetic materials: impact of spin and electronic modulation.

Addressing molecular bistability as a function of external stimuli, especially in spin-crossover (SCO) and metal-to-metal electron transfer (MMET) systems, has seen a surge of interest in the field of molecule-based magnetic materials due to their enormous potential in various technological applications such as molecular spintronics, memory and electronic devices, switches, sensors, and many more. The fine-tuning of molecular components allow the design and synthesis of materials with tailored properties for these vast applications. In this Feature Article, we discuss a part of our research work into this broad topic, pertaining to the recent discoveries in the field of switchable molecular magnetic materials based on SCO and MMET systems, along with some historical background of the area and related accomplishments made in recent years.

Spin-state switching: chemical modulation and the impact of intermolecular interactions in manganese(III) complexes.

A series of mononuclear manganese(III) complexes [Mn(X-sal-323)](ReO) (X = 5 Cl, 1; X = 5 Br, 2; X = 3,5 Cl, 3; X = 3,5 Br, 4; and X = 5 NO, 5), containing hexadentate ligands prepared using the condensation of ,'-bis(3-aminopropyl)ethylenediamine and 5- or 3,5-substituted salicylaldehyde, has been synthesized. Variable temperature single-crystal X-ray diffraction, magnetic, spectroscopic, electrochemical, and spectroelectrochemical analyses, and theoretical calculations have been used to explore the role of various ligand substituents in the spin-state switching behavior of the prepared manganese(III) complexes. All five complexes consist of an analogous distorted octahedral monocationic MnNO surrounding offered by the flexible hexadentate ligand and ReO as the counter anion.

Near room temperature stepwise spin state switching and photomagnetic effect in a mixed-valence molecular square.

A two-step thermo-induced spin-state switching was observed in a cyanide-bridged [FeFe] molecular square complex, {[Fe(pzTp)(CN)][Fe(L)]}[Fe(pzTp)(CN)]·4CHOH·2HO [1·4MeOH·2HO; pzTp = tetrakis(pyrazol-1-yl)borate and L = bis(1-ethylimidazol-2-yl)ketone (bik*)], which was characterized fully by single-crystal X-ray diffraction, (photo)magnetic measurements, and spectroscopic techniques. 1·4MeOH·2HO exhibited a two-step thermo-induced spin transition with (1) ↑ = 306 K and (2) ↑ = 370 K converting the low-temperature ground state, {[(FeIIILS)(FeIILS)](FeIIILS)} into the high-temperature state, {[(FeIIILS)(FeIIHS)](FeIIILS)} a stable intermediate phase. The desolvated phase, 1 also exhibited a gradual but reversible thermo-induced spin state change with a value of 190 K, significantly shifted to a lower temperature.

Realizing the Lowest Bandgap and Exciton Binding Energy in a Two-Dimensional Lead Halide System.

Finding stable analogues of three-dimensional (3D) lead halide perovskites has motivated the exploration of an ever-expanding repertoire of two-dimensional (2D) counterparts. However, the bandgap and exciton binding energy in these 2D systems are generally considerably higher than those in 3D analogues due to size and dielectric confinement. Such quantum confinements are most prominently manifested in the extreme 2D realization in ()PbI ( = 1 or 2) series of compounds with a single inorganic layer repeat unit.

Peripartum cardiomyopathy: A review.

Peripartum cardiomyopathy is a rare type of heart failure manifesting towards the end of pregnancy or in the months following delivery, in the absence of any other cause of heart failure. There is a wide range of incidence across countries reflecting different population demographics, uncertainty over definitions and under-reporting. Race, ethnicity, multiparity and advanced maternal age are considered important risk factors for the disease.

ON/OFF Photo(switching) along with Reversible Spin-State Change and Single-Crystal-to-Single-Crystal Transformation in a Mixed-Valence Fe(II)Fe(III) Molecular System.

A mixed-valence Fe(II)Fe(III) molecular system, {[Fe(pzTp)(CN)][Fe(bik)]}·[Fe(pzTp)(CN)]·4MeOH (·4MeOH) (bik = bis-(1-methylimidazolyl)-2-methanone, pzTp = tetrakis(pyrazolyl)borate), exhibits single-crystal-to-single-crystal (SC-SC) transformation while increasing the temperature and is converted into {[Fe(pzTp)(CN)][Fe(bik)]}·[Fe(pzTp)(CN)] (). Both complexes exhibit thermo-induced spin-state switching behavior along with reversible SC-SC transformation, where the low-temperature [FeFe] phase transforms into a high-temperature [FeFe] phase. ·4MeOH exhibits an abrupt spin-state switching with at 355 K, whereas undergoes a gradual and reversible spin-state switching with a lower at 338 K.

A bis-NHC-CAAC dimer derived dicationic diradical.

The isolation of carbon-centered diradicals is always challenging due to synthetic difficulties and their limited stability. Herein we report the synthesis of a -1,4-cyclohexylene bridged bis-NHC-CAAC dimer derived thermally stable dicationic diradical. The diradical character of this compound was confirmed by EPR spectroscopy.

Push and Pull Effect of Methoxy and Nitro Groups Modifies the Spin-State Switching Temperature in Fe(III) Complexes.

We have explored the impact of electron-donating (methoxy) and electron-withdrawing (nitro) substituents on SalEen ligand based spin crossover (SCO) behavior of Fe(III) complexes. Thus, 3-X-substituted SalEen ligands were employed to prepare [Fe(3-X-SalEen)]·NCSe, where X = OMe (), H (), and NO () (3-X-SalEen is the condensation product of 3-substituted salicylaldehyde and -ethylethylenediamine). The characteristic spin transition temperature ( ) is shown to shift to a lower temperature when an electron-donating substituent (OMe) is used and to a higher temperature when an electron-withdrawing substituent (NO) is used.

Impact of Counteranion on Reversible Spin-State Switching in a Series of Cobalt(II) Complexes Containing a Redox-Active Ethylenedioxythiophene-Based Terpyridine Ligand.

The self-assembly of a redox-active ethylenedioxythiophene (EDOT)-terpyridine-based tridentate ligand and cobalt(II) unit with different counteranions has led to a series of new cobalt(II) complexes [Co()](X) (X = BF (), ClO (), and BPh ()) ( = 4'-(3,4-ethylenedioxythiophene)-2,2':6',2″-terpyridine). The impact of various counteranions on stabilization and spin-state switching of the cobalt(II) center was explored through detailed magneto-structural investigation using variable temperature single-crystal X-ray diffraction, magnetic, spectroscopic, electrochemical, and spectroelectrochemical studies. All three complexes - consisted of an isostructural dicationic distorted octahedral CoN coordination environment offered by the two ligands in a bis-meridional fashion and BF, ClO, and BPh as a counteranion, respectively.

Cabin1 domain-containing gene picd-1 interacts with pry-1/Axin to regulate multiple processes in Caenorhabditis elegans.

The Axin family of scaffolding proteins control diverse processes, such as facilitating the interactions between cellular components and providing specificity to signaling pathways. While several Axin family members have been discovered in metazoans and shown to play crucial roles, their mechanism of action are not well understood. The Caenorhabditis elegans Axin homolog, pry-1, is a powerful tool for identifying interacting genes and downstream effectors that function in a conserved manner to regulate Axin-mediated signaling.

The FGFR4 Homolog KIN-9 Regulates Lifespan and Stress Responses in .

Fibroblast growth factor receptors (FGFRs) regulate diverse biological processes in eukaryotes. The nematode is a good animal model for studying the roles of FGFR signaling and its mechanism of regulation. In this study, we report that KIN-9 is an FGFR homolog in that plays essential roles in aging and stress response maintenance.

Tuning of spin crossover properties in a series of mononuclear cobalt(II) complexes based on a macrocyclic tetradentate ligand and pseudohalide coligands.

The three mononuclear cobalt(II) complexes, [Co(L)(NCX)] (L = ,'-di--butyl-2,11-diaza[3,3](2,6)pyridinophane, and X = S (1), Se (2), and [C(CN)] (3)), have been synthesized and characterized using variable temperature single-crystal X-ray crystallography, and spectroscopic, magnetic, and electrochemical studies. All three complexes have a similar distorted octahedral CoN coordination geometry produced by the macrocyclic tetradentate ligand L and two NCX co-ligands in the position. Complexes 1 and 2 crystallized in the monoclinic 2/ ( = 4) space group, while complex 3 was isolated in the monoclinic 2/ ( = 4) space group.

Effect of Ligand Chain Length for Tuning of Molecular Dimensionality and Magnetic Relaxation in Redox Active Cobalt(II) EDOT Complexes (EDOT=3,4-Ethylenedioxythiophene).

Four cobalt(II) complexes, [Co(L1) (NCX) (MeOH) ] (X=S (1), Se (2)) and {[Co(L2) (NCX) ]}n (X=S (3), Se (4)) (L1=2,5-dipyridyl-3,4,-ethylenedioxylthiophene and L2=2,5-diethynylpyridinyl-3,4-ethylenedioxythiophene), were synthesized by incorporating ethylenedioxythiophene based redox-active luminescence ligands. All these complexes have been well characterized using single-crystal X-ray diffraction analyses, spectroscopic and magnetic investigations. Magneto-structural studies showed that 1 and 2 adopt a mononuclear structure with CoN O octahedral coordination geometry while 3 and 4 have a 2D [4×4] rhombic grid coordination networks (CNs) where each cobalt(II) center is in a CoN octahedral coordination environment.

Impact of counter anions on spin-state switching of manganese(III) complexes containing an azobenzene ligand.

Four mononuclear manganese(III) complexes coordinated with photo-active hexadentate azobenzene ligands, [Mn(5azo-sal-323)](X) (X = Cl, 1; X = BF, 2; X = ClO, 3; X = PF, 4), were prepared. The impact of various counter anions on the stabilization and switching of the spin state of the manganese(III) center was explored through detailed magneto-structural investigation using variable temperature single-crystal X-ray diffraction, magnetic, spectroscopic, and spectroelectrochemical studies, along with theoretical calculations. All four complexes consisted of an isostructural monocationic distorted octahedral MnNO coordination environment offered by the hexadentate ligand and Cl, BF, ClO, and PF as counter anions respectively.

Assembly of a coordination polymer with sulphate-capped pentamolybdate units and copper: synthesis, structure, magnetic and catalytic studies.

A new coordination polymer based on the sulphate-capped pentamolybdate unit has been synthesized from the reaction of {MoSBr} with copper(II) bromide and pyridine, in DMF. The as-synthesized compound, formulated as [Cu(CHN)][{MoVI5O(SO)}{Cu(CHN)(DMF)(HO)}][MoVI5O(SO)]·2DMF (1), crystallizes in the monoclinic space group of 2/. This compound has a one-dimensional double-chain coordination polymeric structure, composed of the pentameric {MoVI5O(SO)} and the {Cu(CHN)} units, and has been characterized in the solid-state with single-crystal and powder X-ray diffraction, infrared and optical spectroscopy, as well as thermal and magnetic studies.

Six-coordinated dinuclear lanthanide(III) amide complexes: investigation of magnetization relaxation dynamics and their electronic structures.

A series of rare six-coordinated dinuclear Ln(III) complexes [Ln(μ-Cl)ClLi(L)(THF)] were structurally characterized using a bulky amide ligand (L; Ln = Gd(1), Dy(2) and Y(3)). Detailed magnetic studies disclose that a weak antiferromagnetic coupling exists within 1 (-0.09 cm) and 2 (-0.

Reported Signs, Symptoms, and Diagnostic Tests Before Cardiotoxicity Among Women With Breast Cancer: A Pilot Study.

Background: Cardiotoxicity after cancer treatment is a potentially preventable life-threatening complication among women with breast cancer. There is no algorithm to identify women with breast cancer at risk of cardiotoxicity.

Objectives: We quantified signs and symptoms as well as selected laboratory values among women with breast cancer who developed cardiotoxicity.

Correlation between soluble receptor for advanced glycation end products levels and coronary artery disease in postmenopausal nondiabetic women.

Background: The established cardiovascular risk factors cannot explain the overall risk of coronary artery disease (CAD), especially in women. Therefore, there is a growing need for the assessment of novel biomarkers to identify women at risk. The receptor for advanced glycation end products (RAGE) and its interaction with the advanced glycation end product (AGE) ligand have been associated with atherogenesis.

Thermo- and photoinduced spin state switching in an iron(II) 2D coordination network associated with large light-induced thermal hysteresis and tuning of dimensionality ligand modulation.

Three iron(ii) complexes, [Fe(L1)2(NCS)2(MeOH)2] (1), [Fe(L1)2(NCSe)2(MeOH)2] (2), and [Fe(L2)2(NCS)2]n (3) (L1 = 2,5-dipyridyl-3,4-ethylenedioxythiophene and L2 = 2,5-diethynylpyridinyl-3,4-ethylenedioxythiophene), have been synthesized using redox-active luminescent ethylenedioxythiophene (EDOT)-based ligands, and characterized by variable temperature single-crystal X-ray diffraction, (photo)magnetic, optical reflectivity, and spectroscopy studies. Magneto-structural investigations revealed that 1 and 2 are mononuclear with a FeN4O2 octahedral coordination geometry and remain in a high-spin (HS) (S = 2) state in a temperature range of 2-280 K. Interestingly, a 2D coordination network structure with FeN6 surrounding each iron center was observed for 3, which exhibits reversible thermo-induced spin-state switching between the paramagnetic high-spin (HS) (S = 2) and diamagnetic low-spin (LS) (S = 0) states at around 105 K (T1/2).

Reversible Photo- and Thermo-Induced Spin-State Switching in a Heterometallic {} WFe Molecular Square Complex.

Following the complex-as-a-ligand strategy, self-assembly of [W(CN)] and iron(II) with bidentate nitrogen donor ligand bik (bik = bis(1-methyl-1-imidazol-2-yl)ketone) ligand affords a cyanide-bridged [WFe] molecular square complex [HNBu]{[W(CN)][Fe(bik)]}·6HO·CHOH (). The complex was characterized by single-crystal X-ray diffraction analyses, (photo)magnetic studies, optical reflectivity, electrochemical studies, and spectroscopic studies. Structural analyses revealed that in the [WFe] square motif tungsten(V) and iron(II) centers reside in an alternate corner of the square and are bridged by the cyanide ligands.