Publications by authors named "Sakkarin Kungsukool"
Aims: Cancer metastasis is a major cause of lung cancer-related mortality, so identification of related molecular mechanisms is of interest. Calmodulin-regulated spectrin-associated protein 3 (CAMSAP3) has been implicated in lung cancer malignancies; however, its role in metastatic processes, including invasion and angiogenesis, is largely unknown.
Main Method: The clinical relevance of CAMSAP3 expression in lung cancer was evaluated.
Article Synopsis
- Lung cancer is the top cause of cancer-related deaths globally, and understanding molecular targets like HDAC6 is crucial for improving diagnosis and treatment outcomes.* -
- Research showed that HDAC6 is overexpressed in lung cancer and linked to poor patient survival. Techniques like qRT-PCR and Western blot were used to analyze its expression.* -
- Inhibition of HDAC6 led to decreased levels of p-ERK, revealing that tubulin acetylation plays a key role in regulating this pathway. Proteomic analysis identified GRP78 as vital for p-ERK's localization to microtubules, altering its stability when HDAC6 is inhibited.*
Microtubule-associated proteins (MAPs) play essential roles in cancer development. This study aimed to identify transcriptomic biomarkers among MAP genes for the diagnosis and prognosis of lung cancer by analyzing differential gene expressions and correlations with tumor progression. Gene expression data of patients with lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) from the Cancer Genome Atlas (TCGA) database were used to identify differentially expressed MAP genes (DEMGs).
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