Increasing trend of -uninfected gastric cancer without gastric atrophy.

The prevalence of () has decreased during several decades due to improvements in the sanitary environment in Japan. Consequently, a relative increase in the incidence of -uninfected gastric cancer is expected. We analyzed the trends in -uninfected gastric cancer.

Brown slits for colorectal adenoma crypts on conventional magnifying endoscopy with narrow band imaging using the X1 system.

Background: Accurate diagnosis of colorectal premalignant polyps, including adenomas, is vital in clinical practice.

Aim: To investigate the diagnostic yields of novel findings of brown slits for adenomas.

Methods: Patients who underwent colonoscopy at the Toyoshima Endoscopy Clinic were enrolled.

Enlarged folds on endoscopic gastritis as a predictor for submucosal invasion of gastric cancers.

Background: Accurate diagnosis of the depth of gastric cancer invasion is crucial in clinical practice. The diagnosis of gastric cancer depth is often made using endoscopic characteristics of the tumor and its margins; however, evaluating invasion depth based on endoscopic background gastritis remains unclear.

Aim: To investigate predicting submucosal invasion using the endoscopy-based Kyoto classification of gastritis.

Consistency between the endoscopic Kyoto classification and pathological updated Sydney system for gastritis: A cross-sectional study.

Background: Two methods are used to evaluate gastritis: the updated Sydney system (USS) with pathology and Kyoto classification, a new endoscopy-based diagnostic criterion for which evidence is accumulating. However, the consistency of their results is unclear. This study investigated the consistency of their results.

Comparison of endoscopic gastritis based on Kyoto classification between diffuse and intestinal gastric cancer.

Background: Gastric cancers can be categorized into diffuse- and intestinal-type cancers based on the Lauren histopathological classification. These two subtypes show distinct differences in metastasis frequency, treatment application, and prognosis. Therefore, accurately assessing the Lauren classification before treatment is crucial.

eradication improved the Kyoto classification score on endoscopy.

Background And Aim: Endoscopy-based Kyoto classification predicts the risk of infection and gastric cancer; however, the change in score following eradication remains unknown. We retrospectively compared the Kyoto score before and after eradication.

Methods: positive patients who underwent baseline esophagogastroduodenoscopy (EGD), successful eradication, and surveillance EGD were enrolled.

Kyoto classification in patients who developed multiple gastric carcinomas after eradication.

Background: Endoscopic Kyoto classification predicts gastric cancer risk; however, the score in the patients with primary gastric cancer after () eradication therapy is unknown.

Aim: To elucidate the Kyoto classification score in patients with both single gastric cancer and multiple gastric cancers developed after eradication.

Methods: The endoscopist recorded the Kyoto classification at the endoscope and the Kyoto classification score at the time of the first diagnosis of gastric cancer after eradication.

Clinical features of cardiac nodularity-like appearance induced by infection.

Background: We have previously reported that ()-associated nodular gastritis could occur in both the antrum and the cardia. Cardiac nodularity-like appearance (hereafter, called as cardiac nodularity) had a high predictive accuracy for the diagnosis of infection. In the previous study, we included only the patients who were evaluated for infection for the first time, and excluded patients with a history of eradication.

Colonoscopy using back brace support belt: A randomized, prospective trial.

Background And Aim: Looping is a major problem in colonoscopy, and it prolongs procedure time. We evaluated the efficacy and safety of an external abdominal compression device (back brace support belt; Maxbelt) with respect to cecal insertion time and other outcomes.

Methods: We performed a prospective study on outpatients undergoing elective colonoscopy in Toyoshima Endoscopy Clinic.

Nodularity-like appearance in the cardia: novel endoscopic findings for infection.

  -associated nodular gastritis, which is associated with follicular lymphoid hyperplasia, is mainly recognized in the antrum. However, we have also observed nodularity-like appearance in the cardia. This study aimed to investigate the clinical significance of cardiac nodularity-like appearance in -associated gastritis.

Adverse events associated with bidirectional endoscopy with midazolam and pethidine.

Same-day bidirectional endoscopy has been reported to reduce recovery time, and procedure-related cost. The safety of bidirectional endoscopy vs colonoscopy only, while using midazolam and pethidine, has never been evaluated. We reviewed 1,202 consecutive patients who underwent bidirectional endoscopy or colonoscopy only with administration of midazolam and pethidine in Toyoshima Ensdoscopy Clinic.

Small-caliber endoscopes are more fragile than conventional endoscopes.

 The repair costs of gastrointestinal endoscopes account for a significant proportion of the total budget of an endoscopy unit. This study evaluated the repair costs of small-caliber endoscopes and conventional endoscopes used in esophagogastroduodenoscopy (EGD).  A retrospective analysis of upper gastrointestinal endoscope damage and repair costs between April 2012 and May 2019 was performed at the Toyoshima Endoscopy Clinic.

CF290 for pancolonic chromoendoscopy improved sessile serrated polyp detection and procedure time: a propensity score-matching study.

 The benefits of the new-generation CF290 (Olympus, Tokyo, Japan) for pancolonic chromoendoscopy (PCC) for colorectal polyp detection and its procedure time remain questionable. We compared the CF290 with the previous CF260 for PCC.  We performed a propensity score-matching study using baseline characteristics such as age, sex, indications, endoscopist, and bowel preparation.

A combination of serum anti- antibody titer and Kyoto classification score could provide a more accurate diagnosis of .

Background: We previously showed that the endoscopic Kyoto classification for gastritis could predict infection in individuals with a high negative titer of serum anti- antibodies. This study evaluated infection and the Kyoto classification score in patients with a low negative titer (<3 U/ml), high negative titer (3-9.9 U/ml), low positive titer (10-49.

Serum anti- antibody titer and its association with gastric nodularity, atrophy, and age: A cross-sectional study.

Aim: To clarify the role of serum anti- () antibody titers in gastric cancer.

Methods: In this cross-sectional study, the effect of patients' baseline characteristics and endoscopic findings on their serum antibody titers were assessed. We evaluated consecutive patients who underwent esophagogastroduodenoscopy and their first evaluation for infection using a serum antibody test.

Early detection of gastric cancer after Helicobacter pylori eradication due to endoscopic surveillance.

Background: Helicobacter pylori eradication therapy is commonly performed to reduce the incidence of gastric cancer. However, gastric cancer is occasionally discovered even after successful eradication therapy. Therefore, we examined the prognosis of gastric cancer patients, diagnosed after successful H.

Adhesive Interactions between Mononuclear Phagocytes and Intestinal Epithelium Perturb Normal Epithelial Differentiation and Serve as a Therapeutic Target in Inflammatory Bowel Disease.

Background And Aims: Disturbance of intestinal homeostasis is associated with the development of inflammatory bowel disease [IBD], and TGF-β signalling impairment in mononuclear phagocytes [MPs] causes murine colitis with goblet cell depletion. Here, we examined an organoid-MP co-culture system to study the role of MPs in intestinal epithelial differentiation and homeostasis.

Methods: Intestinal organoids were co-cultured with lamina propria leukocytes and bone marrow-derived dendritic cells [BMDCs] from CD11c-cre Tgfbr2fl/fl mice.

Overexpression of HER2 in the pancreas promotes development of intraductal papillary mucinous neoplasms in mice.

Pancreatic ductal adenocarcinoma (PDA) has a 5-year survival rate of less than 5% and is the sixth leading cause of cancer death. Although KRAS mutations are one of the major driver mutations in PDA, KRAS mutation alone is not sufficient to induce invasive pancreatic cancer in mice model. HER2, also known as ERBB2, is a receptor tyrosine kinase, and overexpression of HER2 is associated with poor clinical outcomes in pancreatic cancer.

infection in subjects negative for high titer serum antibody.

Aim: To investigate the clinicopathological features of the patients testing negative for high titer serum anti- () antibody.

Methods: The antibody titers were measured using antigens derived from Japanese individuals. C-urea breath test-positive individuals were defined as having infection.

Decline in perception of acid regurgitation symptoms from gastroesophageal reflux disease in diabetes mellitus patients.

Objectives: To determine if a discrepancy exists between subjective symptoms and the grade of endoscopic gastroesophageal reflux disease (GERD) in diabetes mellitus (DM) patients.

Methods: All 2,884 patients who underwent esophagogastroduodenoscopy completed the modified Gastrointestinal Symptom Rating Scale (GSRS), an interview-based rating scale consisting of 16 items including a question on acid regurgitation. Patients were divided into DM and non-DM groups (1,135 and 1,749 patients, respectively).

Decrease in expression caused by infection may promote progression to severe gastritis.

SNP rs2294008 in () and decreased expression are associated with gastric cancer. The objective of this study is to investigate the role of rs2294008 and expression in the gastritis-gastric cancer carcinogenic pathway. We conducted a case-control association study of -infected gastritis and gastric cancer.

CXCR4-expressing progenitors in the gastric antrum contribute to gastric cancer development.

was recently shown to identify a discrete population of stem cells within the isthmus of the oxyntic gland within the gastric corpus. Chief cells at the base of the gastric corpus also express . The relevance of expression as a marker of specific cell populations within the antral glands of the distal stomach, however, is unknown.

Family history is an independent risk factor for the progression of gastric atrophy among patients with infection.

Background And Aim: Risk factors for progression of gastric atrophy have not been fully elucidated. The aim of this study was to evaluate the risk factors for the development of atrophic gastritis in patients with ( ) infection.

Methods: We reviewed 206 -infected patients retrospectively.

The G-protein coupled receptor 56, expressed in colonic stem and cancer cells, binds progastrin to promote proliferation and carcinogenesis.

Overexpression of human progastrin increases colonic mucosal proliferation and colorectal cancer progression in mice. The G-protein coupled receptor 56 (GPR56) is known to regulate cell adhesion, migration, proliferation and stem cell biology, but its expression in the gut has not been studied. We hypothesized that the promotion of colorectal cancer by progastrin may be mediated in part through GPR56.