One Pot Synthesis and Biological Activity Studies of New Spirooxindoles.

This article reports one-pot synthesis of ten novel spirooxindoles using 5-methyl-2-thiohydantoin, isatin derivatives, and malononitrile in good to high yields (65-90 %). The structures of the synthesized compounds were deduced by H-NMR, C NMR, FT-IR, and Mass spectral data. The antibacterial activity of the compounds was evaluated against two Gram-positive bacteria (Staphylococcus aureus and Bacillus subtilis) and two Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa) based on the Kirby-Bauer method.

Preparation of Some New Pyrazolo[1,5-a]pyrimidines and Evaluation of Their Antioxidant, Antibacterial (MIC and ZOI) Activities, and Cytotoxic Effect on MCF-7 Cell Lines.

This study aims to synthesize some novel pyrazolo[1,5-a]pyrimidine derivatives, and investigate their biological activities. These compounds exhibited good to high antioxidant activities [2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging capabilities]. Among them, Ethyl 5-(2-ethoxy-2-oxoethyl)-7-hydroxy-2-methylpyrazolo[1,5-a]pyrimidine-3-carboxylate (3h) showed the highest antioxidant activity [Half-maximal Inhibitory Concentration (IC )=15.

A new benzothiazole azo dye colorimetric chemosensor for detecting Pb ion.

In this work, a new benzothiazole azo dye sensor (BTS) was synthesized, and its cation binding affinity was studied using the colorimetric method, UV-vis, and H NMR spectral data. The results revealed that the sensor BTS exhibits a remarkable tendency for Pb ion to perform spontaneous visual color change from blue (BTS) to pink (BTS + Pb), without any color change in the aqueous solutions of other cations such as Hg, Cu, Al, Ni, Cd, Ag Ba, K, Co, Mg, Na, Ca, Fe, and Fe ions. The observed selectivity could be due to the formation of the complex (BTS + Pb, which led to a blue shift from 586 nm (BTS) to 514 nm (BTS + Pb) in the UV spectrum.

Preparation of New Spiropyrazole, Pyrazole and Hydantoin Derivatives and Investigation of Their Antioxidant and Antibacterial Activities.

In this study, the synthesis of new spiropyrazoles, pyrazole and hydantoin heterocycles is reported by three component reactions of parabanic acids, hydrazine derivatives, and phenacyl bromides in the presence of triphenylphosphine as a nucleophile and triethylamine as a base in good to high yields (69-91 %). Evaluation of the synthesized compounds revealed a good to excellent antioxidant activities (37.6-96.

Potential of graphene oxide as a drug delivery system for Sumatriptan: a detailed density functional theory study.

The adsorption property of Sumatriptan drug onto graphene oxide (GO) was studied using density functional theory (DFT) calculations. All possible initial positions of drug adsorption were considered to find out which one is energetically favorable. According to the achieved findings, the stronger interactions occurred between the positively polarized parts of the Sumatriptan (i.

Diastereoselective Sonochemical Synthesis of Spirocyclopropaneoxindoles and Evaluation of Their Antioxidant and Cytotoxic Activities.

An efficient diastereoselective synthesis of spirocyclopropaneoxindoles is reported using three-component reactions of various phenacylidenetriphenylphosphorane, isatins and phenacyl bromide under ultrasonic irradiation. The structures of synthesized spirocyclopropaneoxindoles were characterized by their spectral data. The antioxidant activities of the synthesized compounds were evaluated by 1,1-diphenyl-2-picrylhydrazyl radical scavenging assay.

Synthesis and Characterization of Novel Thiazolo[3,2-a]pyrimidine Derivatives and Evaluation of Antioxidant and Cytotoxic Activities.

A series of novel thiazolo[3,2-a]pyrimidines were synthesized and characterized by FT-IR, H, C-NMR and mass techniques. Their antioxidant activities were investigated by 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assay and the results showed that all the synthesized compounds exhibit good antioxidant activity. In addition, it was found that any substituent on the aromatic ring of the products plays an important role in their antioxidant activity.

Preparation and characterization of contact active antibacterial surface based on chemically modified nanofibrillated cellulose by phenanthridinium silane salt.

The main object of this research is chemical modification of the nanofibrillated cellulose (NFC) surface with a phenanthridinium silane salt to develop durable non-leaching antibacterial surface. Initially, (3-trimethoxysilylpropyl) phenanthridinium iodide (TMSPhI) as an antibacterial agent was synthesized using (3-chloropropyl trimethoxysilane) (CPTMS) and phenanthridine in the presence of potassium iodide. Subsequently, NFC was cationized by reaction of its hydroxyl groups with the trimethoxysilane group of TMSPhI to prepare the modified sample (NFC-TMSPhI).

One-pot synthesis of γ -spiroiminolactones and γ -dispiroiminolactones using -disubstituted parabanic acid and thioparabanic acid derivatives.

A direct entry and simple process for the synthesis of [Formula: see text]-spiroiminolactones present in a large number of natural products has been developed. In the first step, the synthesis of parabanic acid derivatives was commenced from the reaction of [Formula: see text]-disubstituted urea and thiourea with oxalyl chloride, then a three-component reaction was carried out with isocyanides, acetylenic esters, and [Formula: see text]-disubstituted parabanic acid derivatives. The method allows the construction of a variety of [Formula: see text]-spiroiminolactone structures in good to high yields starting from readily available precursors.

One-pot, Three-component Synthesis of Dialkyl 4-(alkylamino)-7-alkoxy-5-oxo-1-pyridine-2-yl-1,5-dihydrofuro[3,4-b]pyridine-2,3-dicarboxylate.

A one-pot isocyanide-based three-component reaction of 2-aminopyridine and acetylenic esters with alkyl isocyanides afforded tetraalkyl 4-(alkylamino)-2H-1,2'-bipyridine-2,3,5,6-tetracarboxylate and dialkyl 4-(alkylamino)-7-alkoxy-5-oxo-1-pyridin-2-yl-1,5-dihydrofuro[3,4-b]pyridine 2,3-dicarboxylate in good to high yields under mild reaction conditions.

Indirect chemiluminescence-based determination of catecholamines in pharmaceutical formulations by furandicarboxylate derivative as a novel blue fluorescer in peroxyoxalate-H₂O₂ system.

A novel, simple, cheap, and high sensitivity batch chemiluminescent method for the determination of catecholamine drugs, epinephrine (E), dopamine (DA) and methyldopa (MD) at microgram levels in pharmaceutical formulations is described. The method is based on a chemiluminescence (CL) system arising from the reaction of bis(2,4,6-trichlorophenyl) oxalate (TCPO) with H₂O₂ in the presence of a novel fluorescer, furandicarboxylate, and is proposed as a new analytical method for the determination of catecholamines. The method is based on the inhibition of CL emission by DA and its enhancement by E and MD.

A Facile One-Pot Synthesis of Functionalized 4,8-Dihydropyrano[3,2-b]-pyran-4-ones.

The reactive intermediates generated by the addition of alkyl isocyanides and dialkyl acetylenedicarboxylates were trapped by 5-hydroxy-2-hydroxymethyl-4H-pyran-4-one (kojic acid) to yield functionalized 4,8-dihydropyrano[3,2-b]-pyran-4-ones at ambient temperature in good yields.

One-pot synthesis of 4-arylquinolines from aromatic aminoketones and vinylphosphonium salts.

The addition of acetylenic esters to aromatic amines such as 2-amino benzophenone derivatives in the presence of triphenylphosphine leads to highly functionalized phosphoranes, which undergo an intramolecular Wittig reaction following oxidation to produce quinoline derivatives.

A facile route to diastereomeric phosphorus ylides. Chemoselective synthesis of dialkyl (E)-2-[1-(2-oxocyclopentylidene)ethyl]-2-butenedioates.

2-Acetylcyclopentanone undergoes a smooth reaction with triphenylphosphine and dialkyl acetylenedicarboxylates to produce dialkyl 2-(1-acetyl-2-oxocyclopentyl)-3-(1,1,1-triphenyl-lambda(5)-phosphanylidene)succinates. These compounds undergo intramolecular Wittig reactions in boiling benzene to produce highly strained spirocyclobutene derivatives, which spontaneously undergo ring-opening reactions to produce dialkyl (E)-2-[1-(2-oxocyclopentyliden)ethyl]-2-butenedioates.