Publications by authors named "Sakiko Moriyama"
Pulmonary nodular lymphoid hyperplasia (PNLH) is a very rare disease, and it is difficult to diagnose PNLH and distinguish it from mucosa-associated lymphoid tissue (MALT) lymphoma. In addition, information on bronchoalveolar lavage fluid (BALF) analyses is lacking. We herein report a 36-year-old Japanese woman diagnosed with PLNH by a surgical biopsy and analysis of BALF.
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- * Traditional methods of removal using forceps were unsuccessful, but a cryoprobe, which uses cold to help adhere to the foreign body, ultimately succeeded in extracting the molar.
- * While cryoprobes are usually not ideal for dental materials, they can effectively remove long-term aspirated objects that have retained moisture or mucus.
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- - Heat shock protein 47 (HSP47) is linked to fibrotic diseases and finding compounds that disrupt its interaction with collagen is crucial for developing new treatments.
- - Researchers created a system to test potential HSP47 inhibitors by expressing it as a soluble protein in E. coli and screened over 1000 compounds from a library at Nagasaki University.
- - Out of the screened compounds, 13 showed inhibitory effects, with epigallocatechin-3-O-gallate (a polyphenol from tea) being one of the most effective, indicating that specific structural features are important for its activity against HSP47.
Article Synopsis
- Influenza pneumonia is a serious condition that can lead to respiratory distress and organ failure, but there’s no standard treatment protocol for it.
- A study examined the effects of corticosteroid therapy in patients with severe influenza pneumonia to see if it improved outcomes, comparing those treated with steroids to those who were not.
- Results showed no significant differences in long-term mortality or ICU duration between the two groups, but surprisingly, in-hospital mortality was higher for patients receiving corticosteroids.
Small molecule inhibitor of HSP47 prevents pro-fibrotic mechanisms of fibroblasts in vitro.
Biochem Biophys Res Commun
September 2020
Excessive extracellular matrix deposition, in particular collagen, is an important cause of lung fibrosis. Heat shock protein 47 (HSP47), a collagen-binding protein, plays an important role in the intracellular processing of procollagen. A small molecule that blocks the collagen chaperone function of HSP47 has been reported as an HSP47 inhibitor.
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