Publications by authors named "Sakiko Abe"
Article Synopsis
- A 67-year-old man with type 1 diabetes and other health issues was hospitalized after experiencing right hemiplegia and speech difficulties due to low blood sugar levels.
- After administering glucose, his symptoms resolved, but he had similar episodes three times within 10 days, typically occurring at night.
- A review of cases showed that recurrent hypoglycemic hemiplegia is more common on the right side and often happens at night; proper glucose management is crucial to prevent these episodes.
Background: Three clinical trials have examined the chronic effects of medium-chain triglycerides (MCTs) on muscle mass and function in frail older adults (mean age 85 years old). However, significant increases in muscle mass and some muscle function relative to long-chain triglycerides (LCTs) have yet to be shown, possibly due to the small number of participants in each trial.
Objective: We re-analyzed these previous clinical trials to clarify whether MCT supplementation can increase muscle mass and function.
Comprehensive genomic profiling (CGP) of a metastatic liver tumor biopsy specimen suggested that the patient, who was initially diagnosed with cholangiocarcinoma, had colorectal cancer. The identification of both FBXW7 and APC mutations is deemed characteristic of colorectal cancer. Indeed, subsequent colonoscopy revealed sigmoid colon carcinoma that led to tumor resection followed by systemic chemotherapy.
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- Chordoma is a rare malignant bone tumor linked to notochordal tissue, often resistant to standard treatments like surgery and radiation, leading to tumor recurrence.
- A case study of a 72-year-old man revealed his chordoma had a high tumor mutational burden (TMB) and mutations associated with Lynch syndrome, highlighting a genetic connection.
- The findings suggest that genetic analysis can inform treatment strategies for chordoma, particularly with immune checkpoint inhibitors showing effectiveness in this unusual high TMB case.
Background: Supplementation with medium-chain triglycerides (MCTs) was previously shown to increase muscle function in frail elderly individuals.
Objective: We aimed to assess effects of MCTs on cognition in such individuals.
Methods: We enrolled 64 elderly nursing home residents (85.
Background: The combined supplementation of medium-chain triglycerides (MCTs), l-leucine-rich amino acids, and cholecalciferol was previously shown to increase muscle strength and function in frail elderly individuals.
Objective: We examined whether treatment with MCTs alone is sufficient to increase muscle strength and function and activities of daily living (ADL) in such individuals.
Methods: We enrolled 64 elderly nursing home residents (85.
The combined supplementation of medium-chain triglycerides (MCTs), L-leucine-rich amino acids, and cholecalciferol (vitamin D) increase muscle strength and function in frail elderly individuals. However, their effects on cognition are unknown. We enrolled 38 elderly nursing home residents (mean age±SD, 86.
View Article and Find Full Text PDFBackground: Sarcopenia, the loss of skeletal muscle mass, strength, and function, is common in elderly individuals but difficult to treat.
Objective: A combination of nutrients was investigated to treat sarcopenia in very frail elderly adults.
Methods: We enrolled 38 elderly nursing home residents (11 men and 27 women with a mean ± SD age of 86.