Leukotriene C synthase is a novel PPARγ target gene, and leukotriene C and D activate adipogenesis through cysteinyl LT1 receptors in adipocytes.

Leukotriene (LT) C synthase (LTC4S) catalyzes the conversion from LTA to LTC which is a proinflammatory lipid mediator in asthma and other inflammatory diseases. LTC is metabolized to LTD and LTE, all of which are known as cysteinyl (Cys) LTs and exert physiological functions through CysLT receptors. LTC4S is expressed in adipocytes.