Publications by authors named "Saki Tsuchimochi"
Human papillomavirus 18 (HPV18) is a highly malignant HPV genotype among high-risk HPVs, characterized by the difficulty of detecting it in precancerous lesions and its high prevalence in adenocarcinomas. The cellular targets and molecular mechanisms underlying its infection remain unclear. In this study, we aimed to identify the cells targeted by HPV18 and elucidate the molecular mechanisms underlying HPV18 replication.
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- - This study investigates the unique metabolic characteristics of ovarian clear cell carcinoma (CCC) by comparing it to normal tissues, specifically focusing on increased glutathione synthesis and its role in the cancer's development.
- - Evidence shows that CCC cells experience ferroptosis due to high levels of intracellular iron and lipid peroxides, which lead to cell death when glutathione synthesis is inhibited.
- - The use of a fluorescent imaging probe (gGlu-HMRG) successfully highlights differences in glutathione metabolism, displaying strong fluorescent signals in CCC tumor tissues, potentially aiding in distinguishing cancerous tissues from normal ones.
Background: Small cell carcinoma of the uterine cervix (SCCC) is a rare and highly malignant human papillomavirus (HPV)-associated cancer in which human genes related to the integration site can serve as a target for precision medicine. The aim of our study was to establish a workflow for precision medicine of HPV-associated cancer using patient-derived organoid.
Methods: Organoid was established from the biopsy of a patient diagnosed with HPV18-positive SCCC.
The cellular origins of cervical cancer and the histological differentiation of human papillomavirus (HPV)-infected cells remain unexplained. To gain new insights into the carcinogenesis and histological differentiation of HPV-associated cervical cancer, we focused on cervical cancer with mixed histological types. We conducted genomic and transcriptomic analyses of cervical cancers with mixed histological types.
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- Homologous recombination (HR) is crucial for repairing DNA double-strand breaks and is linked to cancer, with HR deficiency being a target for therapy.
- A novel HR factor, MED1, was identified as a binding partner of BRCA1, enhancing BRCA1's transcription ability and participating in DNA damage response processes.
- MED1 depletion led to impaired HR activity and increased accumulation of harmful R-loops, indicating its important role in regulating the HR pathway and managing R-loop processing.
Acute fatty liver of pregnancy (AFLP) is a rare disorder that typically develops in the third trimester. We successfully diagnosed and treated a case of AFLP that developed at 18 weeks' gestation. A 34-year-old woman-gravida 4, para 3-presented with continuous vomiting and abdominal pain and developed convulsive seizures and lost consciousness after transfusion therapy.
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