Publications by Saki Okano | LitMetric

Publications by authors named "Saki Okano"

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Dimethyl Fumarate Reduces Methylglyoxal-derived Carbonyl Stress Through Nrf2/GSH Activation in SH-SY5Y Cells.

Shin Koike Satori Tsurudome Saki Okano Atsushi Kishida Yuki Ogasawara

Neurochem Res

November 2024

Article Synopsis

Carbonyl stress is caused by the buildup of advanced glycation end products (AGEs) and is linked to diseases like diabetes and neurodegenerative disorders, including multiple sclerosis (MS).
The study explores how dimethyl fumarate (DMF), which activates the Nrf2 pathway, can counteract carbonyl stress and protect neuronal cells from damage caused by Methylglyoxal (MGO).
Findings show that DMF enhances glutathione levels and reduces harmful MG-H1-modified protein accumulation in cells, indicating that the Nrf2 pathway is crucial for the protective effects of DMF.

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