Gelsolin alleviates rheumatoid arthritis by negatively regulating NLRP3 inflammasome activation.

Despite numerous biomarkers being proposed for rheumatoid arthritis (RA), a gap remains in our understanding of their mechanisms of action. In this study, we discovered a novel role for gelsolin (GSN), an actin-binding protein whose levels are notably reduced in the plasma of RA patients. We elucidated that GSN is a key regulator of NLRP3 inflammasome activation in macrophages, providing a plausible explanation for the decreased secretion of GSN in RA patients.

Generation and characterization of cerebellar granule neurons specific knockout mice of Golli-MBP.

Golli-myelin basic proteins, encoded by the myelin basic protein gene, are widely expressed in neurons and oligodendrocytes in the central nervous system. Further, prior research has shown that Golli-myelin basic protein is necessary for myelination and neuronal maturation during central nervous system development. In this study, we established Golli-myelin basic protein-floxed mice to elucidate the cell-type-specific effects of Golli-myelin basic protein knockout through the generation of conditional knockout mice (Golli-myelin basic proteins; E3CreN), in which Golli-myelin basic proteins were specifically deleted in cerebellar granule neurons, where Golli-myelin basic proteins are expressed abundantly in wild-type mice.

[Characteristics of the Z-resolution Measurement in the Digital Breast Tomosynthesis].

Purpose: Digital breast tomosynthesis (DBT) offers a choice of image acquisition conditions. The object of observation is the entire detector in the full depth (Z-axis) direction. In this study, we investigated the effect of each acquisition condition on Z-resolution with a micro-metallic sphere (bead) as an imaged object in DBT images.

Arm-cleavable microgel star polymers: a versatile strategy for direct core analysis and functionalization.

Arm-cleavable microgel star polymers were developed, where the arm chains can readily be cleaved by acidolysis after the synthesis, allowing isolation of the core, direct analysis of its structure, and also the creation of functional nanometer-sized microgels. The key is to employ a macroinitiator (PEG-acetal-Cl) that carries an acetal linkage between a poly(ethylene glycol) arm chain and a chloride initiating site. From this, star polymers were synthesized via the linking reaction with a divinyl monomer and a ruthenium catalyst in living radical polymerization.