Publications by authors named "Saki Endo"

Article Synopsis
  • PICC placement using ultrasound guidance is a preferred method for gaining central access in children, but it poses risks for small, unstable infants.
  • A case study highlights the complications of accidental arterial placement in a two-month-old with heart issues, emphasizing the challenges in differentiating between arteries and veins during the procedure.
  • Proper knowledge of vascular anatomy, scanning techniques, and careful preparation are crucial for safely performing PICC placement in vulnerable infants.
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The impact of inorganic nanosheets with various chemical compositions and properties at different concentrations on the rheological properties and the gelation formation of a thermo-responsive hydrogel was investigated. F127 Pluronic triblock copolymers, with the structure (EO)(PO)(EO) (EO: ethylene oxide and PO propylene oxide respectively), functionalized by dimethacrylate (F127-DMA) at a concentration of 25% was used in this study. After careful characterization by complementary techniques: transmission electron microscopy (TEM), atomic force microscopy (AFM), and X-ray diffraction of nanosheets derived from the peeling of layered materials (montmorillonite, organoclays and hexaniobate), the nanosheets were seen to be suitably dispersed in the hydrogels.

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The average age of patients with type 2 diabetes in Japan is over 70 years. Elderly patients tend to have poor medication compliance, therefore, it is important to understand their individual situations to improve medication compliance, the treatment of their diabetes, and their quality of life (QOL). This study aimed to identify factors associated with medication compliance in elderly type 2 diabetic patients.

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Background/aim: Studies of biological activity of 2-styrylchromone derivatives focusing on antioxidant, anti-inflammatory, antiviral and antitumor activity are limited. In this study, eighteen synthetic 2-styrylchromone derivatives were investigated for their cytotoxicity against human malignant and non-malignant cells, and then subjected to quantitative structure-activity relationship (QSAR) analysis.

Materials And Methods: Tumor-specificity was calculated by the ratio of mean 50% cytotoxic concentration (CC) against four normal oral cells to that against oral squamous cell carcinoma cell lines.

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A series of eighteen 2-styrylchromone derivatives (see Chart 1) were synthesized and evaluated for their monoamine oxidase (MAO) A and B inhibitory activities. Many of the derivatives inhibited MAO-B comparable to pargyline (a positive control), and most of them inhibited MAO-B selectively. Of the eighteen derivatives, compound 9 having methoxy group at R and chlorine at R showed both the best MAO-B inhibitory activity (IC = 17 ± 2.

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