Publications by authors named "Saket S Toshniwal"

Psychosis is a complex mental health condition that can have a profound impact on individuals and their families. It is characterized by a loss of contact with reality, including delusions, hallucinations, and disorganized thinking. While psychosis is most commonly associated with psychiatric disorders such as schizophrenia, it is crucial to consider other potential causes to ensure accurate diagnosis and appropriate treatment.

View Article and Find Full Text PDF
Article Synopsis
  • A 7-year-old boy presented with severe seizures and neurological decline, initially showing symptoms like visual changes and cognitive deterioration over six months.
  • MRI scans indicated white matter lesions and elevated serum levels of certain fatty acids, leading to a provisional diagnosis of X-linked cerebral adrenoleukodystrophy (ALD).
  • Despite treatment, the patient's condition worsened to blindness and a vegetative state, underscoring the need for early diagnosis and intervention to manage ALD more effectively.
View Article and Find Full Text PDF

Background Type 2 diabetes mellitus (T2DM) is a prevalent chronic condition characterized by hyperglycemia, which can lead to various microvascular complications, including diabetic nephropathy, neuropathy, and retinopathy. Identifying reliable biomarkers for early detection and risk stratification of these complications is crucial for improving patient outcomes. Adenosine deaminase (ADA) and HbA1c have emerged as potential markers associated with immune function, inflammation, and long-term glycemic control.

View Article and Find Full Text PDF

Porencephaly is an uncommon neurological condition characterized by cystic cavities or holes in the cerebral hemispheres of the brain filled with cerebrospinal fluid. There are two types of porencephaly: acquired porencephaly, also known as pseudo-porencephaly, and congenital porencephaly, also known as true porencephaly. Acquired porencephaly, also known as encephaloclastic porencephaly, typically results from late prenatal or perinatal vascular lesions caused by arterial ischemic stroke or venous thrombosis.

View Article and Find Full Text PDF

Coronaries arise normally from the aortic sinus which consists of one anterior and two posterior cusps of which the right coronary artery (RCA) arises from the anterior cusp and the left coronary artery arises from the left posterior cusp. Abnormal origin of coronary arteries is very rare and counts for about 2.33% of prevalence and below 1% incidence and are comparatively very difficult to diagnose through routine investigations.

View Article and Find Full Text PDF
Article Synopsis
  • * The review discusses advancements in diagnosing AF using various methods, from traditional tests to new wearable technologies, and evaluates current medications and non-drug treatments such as catheter ablation.
  • * It emphasizes personalized care for different patient groups and explores future strategies in AF treatment, including gene therapy and precision medicine, providing a comprehensive overview for healthcare professionals.
View Article and Find Full Text PDF

Marchiafava-Bignami disease (MBD) is uncommon and typically linked with persistent alcohol consumption; nevertheless, instances have been reported in non-alcoholic individuals with nutritional deficiencies. Depending on the severity, this condition may manifest as acute, subacute, or chronic neurological signs and symptoms, ranging from moderate dysarthria or mild disorientation to coma and death. We report a case of a 30-year-old, 14-week pregnant female who presented with complaints of persistent vomiting and loss of appetite.

View Article and Find Full Text PDF
Article Synopsis
  • * This case report discusses a patient with a history of binge drinking who experienced catatonia during alcohol withdrawal, highlighting its unusual occurrence.
  • * The rarity and complexity of catatonia in this context emphasize the need for healthcare providers to be vigilant and aware of its symptoms to avoid misdiagnosis.
View Article and Find Full Text PDF

An unidentified source of increased intracranial pressure is a hallmark of idiopathic intracranial hypertension (IIH), also referred to as pseudotumor cerebri. It mainly affects young, obese women, yet it can happen to anyone, regardless of age, gender, or weight. IIH presents with symptoms such as headaches, visual disturbances, and pulsatile tinnitus and can lead to severe complications, including vision loss, if left untreated.

View Article and Find Full Text PDF