Publications by authors named "Sakari Nikinmaa"
New means to reduce excessive antibiotic use are urgently needed. This study tested dual-light aPDT against biofilm with different relative ratios of light energy with indocyanine green. We applied single-light aPDT (810 nm aPDT, 405 aBL) or dual-light aPDT (simultaneous 810 nm aPDT and 405 nm aBL), in both cases, together with the ICG photosensitizer with constant energy of 100 or 200 J/cm.
View Article and Find Full Text PDFPurpose: During cancer treatment, oral mucositis due to radiotherapy or chemotherapy often leads to disruption of the oral mucosa, enabling microbes to invade bloodstream. Viridans streptococcal species are part of the healthy oral microbiota but can be frequently isolated from the blood of neutropenic patients. We have previously shown the antibacterial efficacy of dual-light, the combination of antibacterial blue light (aBL) and indocyanine green photodynamic therapy (aPDT).
View Article and Find Full Text PDFAim: This study aimed to determine the feasibility and first efficacy of indocyanine green (ICG)-assisted antimicrobial photodynamictherapy (aPDT) as activated using LED light to the dental plaque.
Methods: Fifteen healthy adults were assigned to this four-day randomized study. After rinsing with ICG, 100 J/cm of 810 nm LED light was applied to the aPDT-treatment area.
Article Synopsis
- Antibacterial photodynamic therapy (aPDT) and antibacterial blue light (aBL) are promising treatments for periodontitis, particularly when used alongside mechanical cleaning.
- In experiments, the sensitivity of Streptococcus mutans biofilm to aPDT, aBL, and their combined dual-light aPDT was tested, revealing that dual-light was significantly more effective against one-day biofilms.
- However, after repeated daily treatments over several days, the bacterial viability surprisingly improved, indicating potential limitations in the efficacy of continued aPDT and aBL treatments.