Racial and Ethnic Disparities in the Incidence of Anti-NMDA Receptor Encephalitis.

Objectives: To estimate the incidence of anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis.

Methods: We conducted a retrospective cohort study of >10 million person-years of observation from members of Kaiser Permanente Southern California, 2011-2022. The electronic health record of individuals with text-string mention of and were reviewed to identify persons who met diagnostic criteria for anti-NMDAR encephalitis.

Role of the caspase-8/RIPK3 axis in Alzheimer's disease pathogenesis and Aβ-induced NLRP3 inflammasome activation.

The molecular mediators of cell death and inflammation in Alzheimer's disease (AD) have yet to be fully elucidated. Caspase-8 is a critical regulator of several cell death and inflammatory pathways; however, its role in AD pathogenesis has not yet been examined in detail. In the absence of caspase-8, mice are embryonic lethal due to excessive receptor interacting protein kinase 3-dependent (RIPK3-dependent) necroptosis.