Publications by authors named "Sakai F"
Sialyl glycans have several biological functions. We have previously reported on the preparation and bifidogenic activity of milk-derived sialylglycopeptide (MSGP) concentrate containing sialyl -glycans. The current study qualitatively and quantitatively analyzed the sialyl -glycans present in the MSGP concentrate.
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- - The study aimed to assess how common lung cancer is among patients with rheumatoid arthritis (RA) and identify factors that predict its occurrence.
- - Out of 771 RA patients followed for an average of 9.3 years, different lung conditions showed varied lung cancer incidence rates, with CPFE patients at the highest risk (47.8 cases per 1,000 patient-years).
- - Findings suggest that RA patients with smoking history and pulmonary complications, particularly CPFE, should be closely monitored for lung cancer risk.
Background: Few studies of migraine have evaluated migraine disability across multiple countries using the same methodology.
Methods: This cross-sectional, web-based survey was conducted in 2021-2022 in Canada, France, Germany, Japan, UK and USA. Respondents with migraine were identified based on modified International Classification of Headache Disorders, 3rd edition, criteria.
Aims: To investigate the molecular events associated with acquiring macrolide resistance genes [mefE/mel (Mega) or ermB] in Streptococcus pneumoniae (Spn) during nasopharyngeal colonization.
Methods And Results: Genomic analysis of 128 macrolide-resistant Spn isolates revealed recombination events in genes of the conjugation apparatus, or the competence system, in strains carrying Tn916-related elements. Studies using confocal and electron microscopy demonstrated that during the transfer of Tn916-related elements in nasopharyngeal cell biofilms, pneumococcal strains formed clusters facilitating their acquisition of resistance determinants at a high recombination frequency (rF).
Objective: To assess rates of traversing barriers to care to access optimal clinical outcomes in people with migraine internationally.
Background: People in need of medical care for migraine should consult a health care professional knowledgeable in migraine management, obtain an accurate diagnosis, and receive an individualized treatment plan, which includes scientific society guideline-recommended treatments where appropriate.
Methods: The Chronic Migraine Epidemiology and Outcomes-International (CaMEO-I) Study was a cross-sectional, web-based survey conducted from July 2021 through March 2022 in Canada, France, Germany, Japan, the United Kingdom, and the United States (US).
Objective: This study aimed to describe the migraine burden and healthcare utilization in the context of headache frequency using nationwide claims data linked to online survey data previously collected in Japan.
Background: It has been shown that increase in headache frequency can impose greater impact on individuals' daily and social functioning, but migraine burden in those with low-frequency headaches remains largely unknown in Japan.
Methods: This , observational study reported on 674 respondents who were working individuals and their family members aged 19-74 years, responded to an online questionnaire (response rate: 14.
Article Synopsis
- Atogepant is an oral medication designed to prevent chronic migraines and was tested in a study involving participants with and without medication overuse.
- The study involved 755 adults and assessed the impact of two dosages of atogepant compared to a placebo over 12 weeks, measuring changes in headache and migraine days.
- Results showed significant reductions in migraine and headache days, along with reduced medication use, particularly in participants treated with atogepant, highlighting its effectiveness in managing chronic migraines.
Background: Surveys using questionnaires to collect epidemiologic data may be subject to misclassification. Here, we analyzed a headache questionnaire to evaluate which questions led to a classification other than migraine.
Methods: Anonymized surveys coupled with medical claims data from individuals 19-74 years old were obtained from DeSC Healthcare Inc.
Background And Objectives: Fremanezumab is an effective treatment for episodic (EM) and chronic migraine (CM) patients in Japan, but its cost effectiveness remains unknown. The objective of this study was to determine the cost effectiveness of fremanezumab compared with standard of care (SOC) in previously treated EM and CM patients from a Japanese healthcare perspective.
Methods: Estimated regression models were implemented in a probabilistic Markov model to inform effectiveness and health-related quality-of-life data for fremanezumab and SOC.
Objective: To analyze data from the Chronic Migraine Epidemiology and Outcomes-International (CaMEO-I) Study in order to characterize preventive medication use and identify preventive usage gaps among people with migraine across multiple countries.
Background: Guidelines for the preventive treatment of migraine are available from scientific organizations in various countries. Although these guidelines differ among countries, eligibility for preventive treatment is generally based on monthly headache day (MHD) frequency and associated disability.
Heavy-ion beam, a type of ionizing radiation, has been applied to plant breeding as a powerful mutagen and is a promising tool to induce large deletions and chromosomal rearrangements. The effectiveness of heavy-ion irradiation can be explained by linear energy transfer (LET; keV µm). Heavy-ion beams with different LET values induce different types and sizes of mutations.
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- Human milk is rich in carbohydrates, specifically human milk oligosaccharides (HMOs) and various types of glycans, but the specific profile of glycans had not been thoroughly studied until now.
- This study employed label-free chromatography-mass spectrometry (LC-MS) to analyze the variation in glycan composition and concentration in 200 samples of Japanese human milk from mothers 1-2 months postpartum.
- Findings showed that the presence of fucose linked to galactose affected the abundance of certain glycans and HMOs, with secretor mothers producing more of these compounds compared to nonsecretors, although the overall profile of glycans remained unchanged.
Article Synopsis
- A study was conducted in Japan to assess the real-world effectiveness and safety of CGRP monoclonal antibodies, specifically galcanezumab, fremanezumab, and erenumab, for migraine prevention in patients who failed traditional treatments.
- The research analyzed 68 migraine patients and found a significant reduction in monthly migraine days (from 13.4 to 7.4) and a lower headache impact score after three doses of the CGRP mAbs, indicating their efficacy.
- The treatment was well tolerated, with constipation being the most common side effect, and no serious adverse events were reported, ensuring that patients could continue their therapy without complications.
Aim: (Spn) acquires genes for macrolide resistance, MEGA or , in the human host. These genes are carried either in the chromosome, or on integrative conjugative elements (ICEs). Here, we investigated molecular determinants of the acquisition of macrolide resistance.
View Article and Find Full Text PDFObjectives: To evaluate the 1-year efficacy and safety of once-monthly erenumab 70 mg following a 24-week double-blind treatment period (DBTP) of a phase III randomised study of Japanese patients with episodic migraine (EM) or chronic migraine (CM).
Design: Multicentre open-label study.
Setting: A total of 41 centres in Japan.
Background: The Chronic Migraine Epidemiology and Outcomes-International study provides insight into people with migraine in multiple countries.
Methods: This cross-sectional, observational, web-based cohort study was conducted in Canada, France, Germany, Japan, United Kingdom, and United States. An initial Screening Module survey solicited general healthcare information from a representative sample and identified participants with migraine based on modified criteria; those with migraine completed a detailed survey based on validated migraine-specific assessments.
Article Synopsis
- Migraine is a common and debilitating neurological condition that leads to significant productivity losses at work, yet it is often underrecognized and improperly managed.
- A comprehensive headache education and evaluation program was implemented at Fujitsu, resulting in 90.5% employee participation and a raised awareness of different headache types among staff.
- The program led to increased understanding and empathy towards colleagues with headaches, reduced disability days, and an estimated annual savings of $4,531 in productivity per employee with headaches, suggesting that similar initiatives could benefit other industries.
Introduction: Rapid onset and sustained efficacy are important for acute migraine treatment. Global phase 3 trials have demonstrated the early onset and sustained efficacy of the 5-HT receptor agonist lasmiditan. In this prespecified analysis of the MONONOFU study, we assessed the onset and sustained efficacy of lasmiditan in Japanese patients with migraine.
View Article and Find Full Text PDFMigraine is prevalent, disabling, and peaks during people's peak productive years. The impact of migraine on people's professional lives, work productivity, and interpersonal relationships at work eventually affects everyone, has a significant detrimental effect on people with migraine, and a huge cost in terms of lost productivity. People with migraine want to work, so they do their best to work despite the varied migraine related and associated symptoms.
View Article and Find Full Text PDFBackground: Migraine is a chronic disease characterized by episodic headache attacks. No recent studies have, however been conducted on the epidemiology of migraine or the treatment landscape in Japan. This study was conducted as a fact-finding survey using medical claims data and an online survey on migraine and headaches, conducted among members of health insurance associations with the objective of gaining an understanding of migraine prevalence and the treatment status in Japan.
View Article and Find Full Text PDFPurpose: In two 24-week migraine prevention studies in Japan, erenumab was associated with significantly greater reductions in migraine frequency versus placebo over Weeks 13-24 (primary endpoint). This post hoc analysis evaluated the onset of efficacy within the first 4 weeks after the initiation of erenumab from the 24-week double-blind periods of these studies.
Methods: Placebo-adjusted differences in least squares mean (LSM) change from baseline in weekly migraine days (WMD) were assessed weekly in each study and by migraine type (episodic (EM]/chronic [CM]) (Study 20170609).
The requirement for compensation for diffuse pleural thickening in benign asbestos pleural effusion include five computed tomography findings of organized pleural effusion: [1] heterogeneity in the pleural effusion, [2] declined chest capacity, [3] "crow's feet" sign at the pleura, [4] immobilization of effusion volume, and [5] air in the effusion. Pleural effusion is diagnosed as organized, immobilized, and in the state of diffuse pleural thickening if at least three of these items are fulfilled, ([1] and [3] compulsory + one of the remaining items). This retrospective study investigated whether the requirement to confirm no organized pleural effusion changes after a follow-up of >3 months were available for cases fulfilling three of the five items; i.
View Article and Find Full Text PDFIntroduction: Early discontinuation and poor adherence are common limitations of conventional preventive migraine medications that limit their long-term efficacy. Therefore, a migraine preventive medication with favorable long-term safety is warranted.
Objective: This study aimed to evaluate the long-term safety and tolerability of fremanezumab for the preventive treatment of chronic or episodic migraine in Japanese patients.