Four different malignancies in one patient: a case report.

Cancer survivors have a higher risk of new primary cancer, in the same or in another organ, than the general population. We report a 78-year-old women who has metachronous quadruple adenocarcinoma, includes bilateral breast cancer, ovarian cancer and retroperitoneal neuroendocrine carcinoma. The development of second cancer in cancer survivors can be expected but third or higher order malignancies are rare.

[Scattered papules in three Togolese children from a consanguineous marrige: epidermodysplasia verruciformis].

Epidermodysplasia verruciformis (EV) is a rare condition characterized by diffuse flat wart-like lesions. It is an autosomal recessive genodermatosis associated with susceptibility to infection by specific human papillomavirus genotypes and a high risk of skin cancer. In this report we describe three cases of EV after a consanguineous marriage in a family with no history of EV.

Melanoma metastasis to the breast: a diagnostic pitfall.

Background: Breast metastasis is an extremely rare phenomenon. While nearly every malignancy has been described to metastasize to the breast; melanoma, lymphoma and leukemia tend to be the most common. Among these primary tumors, melanoma metastasis represents a diagnostic pitfall for both the clinicians and histopathologists.

[Clinical safety of a generic fixed-dose combination of stavudine/lamivudine/névirapine (Triomune). Study of 297 cases in Togo].

The aim of this study was to determine the incidence of the side-effects of the fixed dose combination of stavudine/lamivudine/nevirapine (Triomune) during treatment of the HIV infected patients in Togo. It was a multicentric retrospective study carried out from September 2003 to October 2005. We collected data from the medical files of the HIV infected patients using antiretroviral therapy Patients were included in the study if using Triomune and were followed up regularly in an accredited centre of management of HIV infected patients for at least one month.

[Leprosy in Lome, Togo: retrospective study of 383 cases].

The goal of this study was to determine the therapeutic outcomes and clinical forms of leprosy diagnosed in Lomé, Togo. This retrospective study was carried out in leprosy patients managed at the National Center of Dermatology in Lomé between January 1990 and December 2005. During the study period, 383 cases of leprosy were recorded including 366 new cases.

[Systemic lupus erythematosus in Lomé, Togo].

The purpose of this retrospective study was to analyze clinical findings and outcomes in patients treated for systemic lupus erythematosus (SLE) in Lomé, Togo between 1991 and 2003. Review of records from four departments turned up a total of 16 cases of SLE. All patients were women.

A case of paroxysmal nocturnal hemoglobinuria presenting with intra-abdominal bleeding due to splenic rupture, developing renal infarct.

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare disorder characterized by intravascular hemolysis, hemoglobinuria, and thrombosis. Thrombotic attacks are life threatening and are responsible for nearly 50% of PNH-related deaths. Compared with thrombotic events, bleeding related to thrombocytopenia in PNH is quite rare.

Primary biliary cirrhosis and IgG-kappa type multiple myeloma both respond well to vincristine, adriamycin and dexamethasone: is there a pathogenic relationship?

Patients with primary biliary cirrhosis (PBC) are at increased risk for various malignancies including lymphoproliferative diseases. In this report, we describe a 52-year-old man with the simultaneous diagnosis of PBC and IgG-kappa multiple myeloma (MM). Serum cholestatic enzyme (alkaline phosphatase and gamma-glutamyltransferase) levels decreased after three courses of vincristine, adriamycin and dexamethasone treatment followed by six courses of melphalan and methylprednisolone, given for MM.

Immunoglobulin D lambda multiple myeloma and amyloidosis with predominant soft tissue involvement.

Multiple myeloma (MM) is associated with amyloidosis in approximately 15% of the patients. The most frequent presenting signs of such an association are nephrotic syndrome, cardiomyopathy and peripheral neuropathy. Amyloid arthropathy is not a frequent feature.

Treatment anxiety in oral and maxillofacial surgery. Results of a German multi-centre trial.

Background: Oral and Maxillofacial operations can be extremely frightening treatment situations. General data on this phenomenon should be acquired through a multi-centre trial.

Method: A 10-page questionnaire was developed which was answered by 600 oral and maxillofacial patients before individual treatment.

Technetium-99m 2-methoxy-isobutyl-isonitrile uptake scintigraphy in detection of the bone marrow infiltration in multiple myeloma: correlation with MRI and other prognostic factors.

Whole-body scintigraphy with Technetium-99m 2-methoxy-isobutyl-isonitrile ((99m)Tc-MIBI) has been proposed as a useful method for demonstrating the areas of active bone marrow infiltration in multiple myeloma (MM). In this study, we compared the (99m)Tc-MIBI scan with magnetic resonance imaging (MRI), skeletal X-ray survey, and biochemical markers of disease activity in MM to determine its potential in predicting the extension of the disease. Twenty-four myeloma patients had undergone to the (99m)Tc-MIBI scan.

Application of conformal transformation to elliptic geometry for electric impedance tomography.

Electrical impedance tomography (EIT) is a medical imaging modality that is used to compute the conductivity distribution through measurements on the cross-section of a body part. An elliptic geometry model, which defines a more general frame, ensures more accurate results in reconstruction and assessment of inhomogeneities inside. This study provides a link between the analytical solutions defined in circular and elliptical geometries on the basis of the computation of conformal mapping.

[Treatment of generalized cutaneous lichen planus with dipropionate and betamethasone disodium phosphate: an open study of 73 cases].

Objective: The aim of this study was to evaluate the efficacy of treatment of generalized cutaneous lichen planus using dipropionate and betamethasone disodium phosphate.

Patients And Method: A prospective study was conducted among patients presenting generalized cutaneous lichen planus consulting a dermatology service of Lomé teaching hospital in Togo (September 2003 to August 2005). Each patient included in our study reveived three injections of dipropionate and betamethasone disodium phosphate every 2 weeks.

Takayasu arteritis presenting with Fever of unknown origin: two case reports.

Two patients with Takayasu arteritis are reported who presented with fever of unknown origin. Takayasu arteritis was diagnosed at the prepulseless period after stenotic lesions of the aorta, and its branches were seen with imaging methods. In the first month of steroid treatment, hypertension developed in both patients that was related to fibrosis in stenotic lesions in renal arteries.

[Treatment anxiety in oral and maxillofacial surgery].

Background: Oral and maxillofacial operations are stressful treatment situations for patients. Specific data on this phenomenon were acquired through a multicenter study.

Material And Methods: A 10-page questionnaire was answered by 600 oral and maxillofacial patients before individual treatment.

Prognostic importance of soluble CD23 in B-cell chronic lymphocytic leukemia.

Soluble CD23 (sCD23) was proposed as a marker of disease activity and as an important prognostic parameter in B-cell chronic lymphocytic leukemia (B-CLL). In this study, prognostic significance of sCD23 in B-CLL was examined according to its temporal relationship with the known clinical parameters of the disease, CD38 and ZAP-70. Serum sCD23 levels of 36 B-CLL patients, followed up in our clinic between 1999 and 2005, and 15 healthy subjects were measured with enzyme-linked immunosorbent assay.

Fever of unknown origin: a report of 57 cases.

Fever of unknown origin (FUO) is defined as the body temperature higher than 38.3 degrees C on several occasions and lasting longer than 3 weeks, with the aetiology remaining uncertain after 1 week of investigation. In this study, we reviewed 57 patients with FUO hospitalised in our inpatient department between 1998 and 2003.

Acute renal failure due to leukaemic infiltration in chronic lymphocytic leukaemia: case report.

A 73-year-old woman was presented with altered mental status and disorientation. She was diabetic and hypertensive, and she had experienced an ischemic cerebrovascular accident 3 years ago. Physical examination revealed the findings of chronic obstructive pulmonary disease, cor pulmonale and congestive heart failure.