Background/aims: Prospective data on switching anti-vascular endothelial growth factors in patients with neovascular age-related macular degeneration (nAMD) who have previously shown no/partial response are limited. This prospective study assessed the effect of switching from aflibercept to ranibizumab on anatomical and functional outcomes in patients with persistent/recurrent disease activity.
Methods: SAFARI (NCT02161575) was a 6-month, prospective, single-arm study conducted in the UK and Germany.
Purpose: To report the prevalence of ocular morbidity in patients with treated multibacillary Hansen's disease (HD) using modern ophthalmic diagnostic techniques in a rural community endemic for HD.
Design: Cross-sectional, observation study.
Participants: All patients with multibacillary HD who had completed their multidrug therapy and who resided in 4 defined geographical areas in Vellore, Tamil Nadu, India.
We demonstrate a fiber-based programmable arbitrary picosecond optical pulse shaper using binary phase-only linear filtering. The reconfigurable filtering operation is implemented in the time domain using an electro-optical phase modulator driven by a high-speed bit pattern generator. The required binary phase code is designed using a genetic algorithm.
View Article and Find Full Text PDFPurpose: To determine the prevalence of glaucoma in a population of patients with multibacillary Hansen disease who had completed treatment.
Patients And Methods: The authors examined 386 of 446 patients with treated multibacillary Hansen disease residing in a geographically limited area. A complete ophthalmic examination including slit-lamp, applanation tonometry, gonioscopy, ophthalmoscopy, and stereobiomicroscopic examination of the optic disc was performed in all subjects.