Publications by authors named "Saju S Jacob"
Exp Toxicol Pathol
November 2009
Article Synopsis
- Cisplatin is an anticancer drug that causes testicular toxicity in mice even at therapeutic doses, leading to reduced testis weight and abnormal sperm production.
- The study included six groups of mice, with varying doses of cisplatin and some receiving l-ascorbic acid, which showed protective effects on testicular health in certain groups.
- Histological changes in the testes involved tissue damage, vacuoles, and a significant decrease in sperm count and motility, though recovery was noted when l-ascorbic acid was administered.
