DEPTOR promotes survival of cervical squamous cell carcinoma cells and its silencing induces apoptosis through downregulating PI3K/AKT and by up-regulating p38 MAP kinase.

DEPTOR is an endogenous inhibitor of mTOR complexes, de-regulated in cancers. The present study reveals a vital role for DEPTOR in survival of cervical squamous cell carcinoma (SCC). DEPTOR was found to be overexpressed in both cervical SCC cells and tissues and it's silencing in cervical SCC cells induced apoptosis, mainly by up-regulation of p38 MAPK and by inhibiting PI3K/AKT pathway via a feed-back inhibition from mTORC1-S6K.

Occurrence of fatal syngamosis in emu birds of Kerala.

Two male and two female emu birds of 8 months to 1 year old reared in a private farm were brought dead to College of Veterinary and Animal Sciences, Pookode for postmortem examination during the period from July to September, 2010. The birds were emaciated and drooling of blood from the mouth was observed for 2 days prior to death. Postmortem examination of the dead birds revealed occurrence of large numbers of red coloured worms throughout trachea with histopathological changes.