Miller's Syndrome with Bleeding Nasal Polyp.

In this case we report rare clinical entity of Millers syndrome in a small child of 6 years. It is basically an autosomal recessive condition characterized by anomalies of face and limbs such as malar hypoplasia, micrognathia, cleft lip and palate, restricted airway, bones and joints malformations [1, 2]. In this child apart from all these features we came across bleeding nasal masses attached to the inferior tubinates, which were causing complete nasal obstruction.

Effects of Chemical and Herbal Disinfection Methods on the Color Stability of Maxillofacial Silicone: An Study.

Introduction: Maxillofacial prostheses used in rehabilitation of patients are fabricated with medical grade silicone and are tinted corresponding to the patients natural skin color. However, exposure to environment and disinfectants can affect the color stability. Due to rising microorganism resistance and fewer adverse effects of chemical agents, phytoextracts appear to be a viable option.

Activity Protects Spinal Premotor Interneurons from Microglial Phagocytosis and Transneuronal Degeneration After Corticospinal Injury.

Spinal premotor circuits play a fundamental role in motor control. The corticospinal tract (CST) provides control signals to premotor circuits in the spinal cord, guiding voluntary skilled movements. Unilateral selective lesion of the CST in the medullary pyramidal tract (PTX) produces transneuronal degeneration, whereby Choline Acetyltransferase-positive (ChAT) premotor interneurons contralesionally undergo non-apoptotic degeneration by microglial phagocytosis.

A review of high-entropy materials with their unique applications.

High-entropy materials (HEMs) constitute an innovative category of advanced materials distinguished by their distinctive atomic arrangements and remarkable multifunctional attributes. This thorough overview critically analyzes the core principles, synthesis methods, and novel applications of HEMs, emphasizing their transformative potentials in electromagnetic and biological fields. This study examines how the high configurational entropy effect, lattice distortion, and slow diffusion mechanisms facilitate the stabilization of single-phase systems including numerous primary elements.

XLTLDisNet: A novel and lightweight approach to identify tomato leaf diseases with transparency.

Agricultural productivity is essential for global economic development by ensuring food security, boosting incomes and supporting employment. It enhances stability, reduces poverty and promotes sustainable growth, creating a robust foundation for overall economic progress and improved quality of life worldwide. However, crop diseases can significantly affect agricultural output and economic resources.

A review of electrochemical sensing in droplet systems: Droplet and digital microfluidics.

Background: Microfluidic technologies based on droplets provide discrete volumes within which chemical and/or biological processes can take place. Two major platforms in this space include droplet microfluidics (emulsions within channels) and digital microfluidics (discrete droplet manipulation by electric fields). The integration of electrochemical sensing with both microfluidic platforms offers advantages in miniaturization and portability, as sensors can be integrated directly within the microfluidic devices and instrumentation is relatively compact.

D-bait: A siDNA for regulation of DNA-protein kinases against DNA damage and its implications in cancer.

siDNA fragments, also called Dbait and Pbait, are small DNA oligonucleotides of 30-32 base pairs that cause impairment in DNA repair pathways. Like siRNA and miRNA molecules, which lead to the degradation of mRNA molecules through the Argonaute and Drosha machinery, respectively, Dbait molecules act as false DNA damage signals and trigger and exhaust the DNA repair machinery. In normal cells with no significant DNA damage, the influence of these molecules is negligible.

Effectiveness of ertugliflozin during Ramadan fasting in patients with type 2 diabetes mellitus: a real-world study (ErtuRamadan study).

Background: Management of type 2 diabetes mellitus (T2DM) during Ramadan fasting presents unique challenges due to prolonged fasting periods, irregular meal schedules, and altered medication timing, potentially impacting glycemic control. Ertugliflozin, a sodium-glucose co-transporter 2 (SGLT2) inhibitor, has been shown to improve glycemic control in T2DM effectively. However, the effectiveness of ertugliflozin during Ramadan fasting, a period with unique glycemic challenges, has not been studied extensively.

Status of cerebrovascular autoregulation relates to outcome in severe paediatric head injury: STARSHIP, a prospective multicentre validation study.

Background: Continuous assessment of cerebral autoregulation (CA) using pressure reactivity index (PRx), is a promising tool for individualized management to improve outcome after traumatic brain injury (TBI). However, experience with CA in paediatric TBI (pTBI) is limited to retrospective or single-centre studies.

Methods: (clinicalTrials.

Non-malignant gynaecological disease and risk of cardiovascular or cerebrovascular disease: a systematic review and meta-analysis.

Background: Cardiovascular disease is the leading cause of death globally. Non-malignant gynaecological diseases (NMGD) significantly affect patient health and well-being and may be associated with cardiovascular or cerebrovascular disease (C/CVD).

Methods: Seven databases were searched for relevant studies up to 21 April 2024.

Quantifying Nuclear Structures of Digital Pathology Images Across Cancers Using Transport-Based Morphometry.

Alterations in nuclear morphology are useful adjuncts and even diagnostic tools used by pathologists in the diagnosis and grading of many tumors, particularly malignant tumors. Large datasets such as TCGA and the Human Protein Atlas, in combination with emerging machine learning and statistical modeling methods, such as feature extraction and deep learning techniques, can be used to extract meaningful knowledge from images of nuclei, particularly from cancerous tumors. Here, we describe a new technique based on the mathematics of optimal transport for modeling the information content related to nuclear chromatin structure directly from imaging data.

Retraction notice to "Tfh cells potential dual role in cancer: A perspective" [ /19 2024 e37502].

[This retracts the article DOI: 10.1016/j.heliyon.

Exploration of High and Low Molecular Weight Polyacrylic Acids and Sodium Polyacrylates as Potential Binder System for Use in Silicon Graphite Anodes.

The commercialization of silicon anodes requires polymer binders that are both mechanically robust and electrochemically stable in order to ensure that they can accommodate the volume expansion experienced during cycling. In this study, we examine the use of both low and high molecular weight (MW) polyacrylic acids (PAAs), and sodium polyacrylates (Na-PAAs), at different degrees of partial neutralization, as a possible binder candidate for use in silicon graphite anodes. High MW PAAs were found to have stable capacity retentions of 672 mAh g for over 100 cycles, whereas with the low MW PAAs the capacity was found to already have declined to 373 mAh g after the first 30 cycles.

TQGDNet: Coronary artery calcium deposit detection on computed tomography.

Coronary artery disease (CAD) continues to be a leading global cause of cardiovascular related mortality. The scoring of coronary artery calcium (CAC) using computer tomography (CT) images is a diagnostic instrument for evaluating the risk of asymptomatic individuals prone to atherosclerotic cardiovascular disease. State-of-the-art automated CAC scoring methods rely on large annotated datasets to train convolutional neural network (CNN) models.

Stepping into day treatment approach versus inpatient treatment for adults with anorexia nervosa: the DAISIES RCT.

Background: A substantial proportion of anorexia nervosa patients require intensive treatments, commonly inpatient or day-patient treatment. The relative merits of these treatments for adults with anorexia nervosa are unknown. Therefore, a trial investigating the clinical effectiveness and cost-effectiveness of inpatient treatment-as-usual versus a stepped-care day-patient approach in adults with anorexia nervosa (DAISIES) was commissioned.

Addressing the Alarming Rise in Pediatric Cancer Prevalence in India: A Call to Action.

Background: Childhood cancer has become a pressing global concern, impacting over 200,000 children annually, and is projected to escalate to 21 million diagnoses by 2030. This article discusses the growing incidence of pediatric cancer in India, describes the unique obstacles it faces, and encompasses a strategy for solving this pressing problem.

Methods: We reviewed published scientific literature and available information on cancer control and prevention programs in India.

Serial Lactate in Clinical Medicine - A Narrative Review.

Background: Blood lactate is commonly used in clinical medicine as a diagnostic, therapeutic and prognostic guide. Lactate's growing importance in many disciplines of clinical medicine and academic enquiry is underscored by the tenfold increase in publications over the past 10 years. Lactate monitoring is presently shifting from single to serial measurements, offering a means of assessing response to therapy and to guide treatment decisions.

Retraction: Corrective Efficacy of Calcaneal Lengthening Osteotomy for Planovalgus Deformity in Cerebral Palsy Patients.

[This retracts the article DOI: 10.7759/cureus.57092.

Antiplatelet Agents in Endovascular Neurointerventional Procedures.

Minimally invasive, image-guided endovascular procedures are becoming increasingly prevalent as techniques and technologies have advanced, particularly within the realm of neurovascular interventions. Endovascular approaches ubiquitously result in endothelial injury with subsequent risk of thromboembolic complications. Periprocedural antiplatelet agent use is an integral component of the management of patients undergoing endovascular neurointerventional procedures.

Single-Crystal-to-Single-Crystal Synthesis of a Polymer in Two Distinct Topologies.

A squaramide-based monomer, designed for topochemical azide-alkyne cycloaddition (TAAC) polymerization, crystallizes as two polymorphs, M1 and M2, both having crystal packing suitable for topochemical polymerization. The hydrogen-bonding between squaramide units bias the molecular organization in both the polymorphs. 3D packing of H-bonded stacks of monomer lead to juxtaposition of azide and alkyne units of adjacent molecules in a transition-state-like arrangement for their regiospecific cycloaddition reaction.

An overview of the use of non-titanium MXenes for photothermal therapy and their combinatorial approaches for cancer treatment.

Since the initial publication on the first TiCT MXene in 2011, there has been a significant increase in the number of reports on applications of MXenes in various domains. MXenes have emerged as highly promising materials for various biomedical applications, including photothermal therapy (PTT), drug delivery, diagnostic imaging, and biosensing, owing to their fascinating conductivity, mechanical strength, biocompatibility and hydrophilicity. Through surface modification, MXenes can mitigate cytotoxicity, enhance biological stability, and improve histocompatibility, thereby enabling their potential use in biomedical applications.

Evaluation of Phoenix Sepsis Score Criteria: Exploratory Analysis of Characteristics and Outcomes in an Emergency Transport PICU Cohort From the United Kingdom, 2014-2016.

Objectives: To assess characteristics and outcomes of children with suspected or confirmed infection requiring emergency transport and PICU admission and to explore the association between the 2024 Phoenix Sepsis Score (PSS) criteria and mortality.

Design: Retrospective analysis of curated data from a 2014-2016 multicenter cohort study.

Setting: PICU admission following emergency transport in South East England, United Kingdom, from April 2014 to December 2016.