Accurate prediction of protein tertiary structural changes induced by single-site mutations with equivariant graph neural networks.

Predicting the change of protein tertiary structure caused by singlesite mutations is important for studying protein structure, function, and interaction. Even though computational protein structure prediction methods such as AlphaFold can predict the overall tertiary structures of most proteins rather accurately, they are not sensitive enough to accurately predict the structural changes induced by single-site amino acid mutations on proteins. Specialized mutation prediction methods mostly focus on predicting the overall stability or function changes caused by mutations without attempting to predict the exact mutation-induced structural changes, limiting their use in protein mutation study.

Multi-head attention-based U-Nets for predicting protein domain boundaries using 1D sequence features and 2D distance maps.

The information about the domain architecture of proteins is useful for studying protein structure and function. However, accurate prediction of protein domain boundaries (i.e.

Deep Learning Prediction of Severe Health Risks for Pediatric COVID-19 Patients with a Large Feature Set in 2021 BARDA Data Challenge.

Most children infected with COVID-19 have no or mild symptoms and can recover automatically by themselves, but some pediatric COVID-19 patients need to be hospitalized or even to receive intensive medical care (e.g., invasive mechanical ventilation or cardiovascular support) to recover from the illnesses.

High-Performance Deep Learning Toolbox for Genome-Scale Prediction of Protein Structure and Function.

Computational biology is one of many scientific disciplines ripe for innovation and acceleration with the advent of high-performance computing (HPC). In recent years, the field of machine learning has also seen significant benefits from adopting HPC practices. In this work, we present a novel HPC pipeline that incorporates various machine-learning approaches for structure-based functional annotation of proteins on the scale of whole genomes.

Case report: incidental findings of COVID-19 infection on positron emission tomography/computed tomography for staging of a giant gastric gastrointestinal stromal tumor.

We report the incidental finding of COVID-19 in a 59-year-old male, with no significant cardiorespiratory past medical history who underwent a fluorodeoxyglucose positron emission tomography (FDG-PET) scan for investigation of a likely gastric gastrointestinal stromal tumor (GIST). There may be significant discrepancies between clinical symptoms and radiological severity with COVID-19 infection. FDG-PET scanning has the potential to complement traditional radiological imaging in COVID-19 in diagnosis of subclinical diagnosis or early stage disease, as well as monitoring disease progression.

Angiotensin converting enzyme inhibitors do not increase the risk of poor outcomes in COVID-19 disease. A multi-centre observational study.

Background And Aims: Hypertension is associated with an increased risk of severe outcomes with COVID-19 disease. Angiotensin Converting Enzyme (ACE) inhibitors are widely used as a first line medication for the treatment of hypertension in the UK, although their use was suggested in early reports to increase the risk associated with SARS-CoV-2 infection.

Methods: A prospective cohort study of hospitalised patients with laboratory confirmed COVID-19 was conducted across three hospital sites with patients identified on the 9th April 2020.

Hartmann's Pouch Stones and Laparoscopic Cholecystectomy: The Challenges and the Solutions.

Background & Objective: Hartmann's pouch stones (HPS) encountered during laparoscopic cholecystectomy (LC) may hinder safe dissection of the cystic pedicle or be complicated by mucocele, empyema, or Mirizzi syndrome; distorting the anatomy and increasing the risk of bile duct injury. We studied the incidence, presentations, operative challenges, and outcomes of HPS.

Methods: A cohort study of a prospectively maintained database of LCs and bile duct explorations performed by a single surgeon.

Impact of the COVID-19 pandemic on core surgical training.

Background And Aims: COVID-19 pandemic has caused significant disruption in training which is even more pronounced in the surgical specialties. We aim to assess the impact of COVID-19 pandemic on core surgical training.

Methods: All core surgical and improving surgical trainees in West of Scotland region were invited to participate in an online voluntary anonymous survey via SurveyMonkey.

The impact of socioeconomic status on 30-day mortality in hospitalized patients with COVID-19 infection.

Socioeconomic status (SES) impacts outcome in a number of diseases. Our aim was to compare the outcome of hospitalized coronavirus disease 219 (COVID-19) patients in low and high SES group. Prospective cohort study of hospitalized patients with confirmed COVID-19 in three acute hospitals.

Acute pancreatitis following orlistat therapy: report of two cases.

Context: Orlistat is a pancreatic lipase inhibitor licensed for the treatment of obesity. As obesity rates increase and non-prescription dispensing of orlistat increases, an awareness of its adverse effects is of crucial importance as complications arise more frequently from increased use. Orlistat induced pancreatitis has been described only once previously, but without a diagnostic increase in serum amylase.

Cleaning the laparoscopic camera port by a microbiology culture swab.

Introduction: The 5-mm camera is currently widely utilized in Laparoscopic surgery. A disturbing problem for the laparoscopic surgeon is when this Port is becoming smudged by fat or blood, affecting the cleanliness of the 5-mm camera lens after insertion. Due to its narrow, long tube, cleaning this port is tricky.

Primary closure of choledochotomy after emergency laparoscopic common bile duct exploration.

Introduction: The debate into whether or not to drain the common bile duct after laparoscopic common bile duct exploration (LCBDE) for choledocholithiasis continues. Reports are in favour of primary closure of choledochotomy in elective setting. The aim of this study is to evaluate our experience in the primary closure of choledochotomy in emergency setting by analysing indications, operative time, hospital stay, complications, and outcome.