Publications by authors named "Sajeli Ahil Begum"
Introduction: Microtubules play a vital role in cancer therapeutics. They are implicated in tumorigenesis, thus inhibiting tubulin polymerization in cancer cells, and have now become a significant target for anticancer drug development. A plethora of drug molecules has been crafted to influence microtubule dynamics and presently, numerous tubulin inhibitors are being investigated.
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- - Significant advancements in monoclonal antibody therapies have improved their efficacy in oncology, but current antibody-drug conjugates (ADCs) still face challenges regarding safety and effectiveness.
- - The article reviews the obstacles in developing effective ADCs in cancer treatment and offers expert insights on addressing these issues.
- - Future strategies may focus on enhancing cancer cell targeting, site-specific drug conjugation, and overcoming drug resistance to create a new wave of more effective ADCs for cancer patients.
Objectives: The study aimed to explore the anti-inflammatory effect, underlying mechanism, and chemistry of Halodule pinifolia extract.
Methods: The ethyl acetate (EHP) and methanol (MHP) extracts of Halodule pinifolia were screened for pro-inflammatory cytokine inhibition effect under various in vitro (LPSand crystal-induced inflammation) and in vivo models (LPS-induced endotoxaemia model, carrageenan-induced paw oedema model, and oxalate-induced renal nephropathy model of inflammation). The effect of EHP on the expression of inflammatory markers using western blot analysis (in vitro) was investigated.