Noninvasive risk assessment early after a myocardial infarction the REFINE study.

Objectives: This study sought to determine whether combined assessment of autonomic tone plus cardiac electrical substrate identifies most patients at risk of serious events after myocardial infarction (MI) and to compare assessment at 2 to 4 weeks versus 10 to 14 weeks after MI.

Background: Methods to identify most patients at risk of serious events after MI are required.

Methods: Patients (n = 322) with an ejection fraction (EF) <0.