Publications by authors named "Saja Jaberi"
Article Synopsis
- Insulin resistance (IR) may predict how well patients respond to antidepressants, and this study examines changes in IR after treatment and its effect on treatment outcomes.
- The analysis used data from a clinical trial involving 95 adults and found that IR significantly increased in non-responders after treatment, while responders showed reduced IR.
- Changes in IR influenced both the severity of depression measured by the MADRS and the relationship between inflammation (indicated by C-reactive protein) and treatment efficacy, suggesting IR plays a key role in antidepressant response.
Purpose Of Review: Lumateperone (LUM) is the U.S. Food and Drug Administration approved atypical antipsychotic agent for adults with schizophrenia (SCZ) and bipolar depression (for both bipolar I and bipolar II disorder as as monotherapy or as adjunctive treatment to lithium or valproate).
View Article and Find Full Text PDFWhile ketamine has been used clinically over the past decades, it has only been recently shown to be a promising therapy for treatment-resistant depression (TRD). However, ketamine and related dissociative agents may also be misused recreationally, creating significant concerns for abuse liability when prescribed for depression. Although the abuse potential of ketamine is widely recognized, there is limited evidence on the differential abuse liability of ketamine enantiomers, (S)-ketamine and (R)-ketamine.
View Article and Find Full Text PDFIntroduction: The overarching aim of this review is to synthesize the efficacy, tolerability, and weight-mitigation effects of the olanzapine/samidorphan (OLZ/SAM) combination treatment in adults with schizophrenia and bipolar disorder-I.
Methods: A systematic search of PubMed, Web of Science, Embase, and The Cochrane Library was conducted on August 15th, 2021. Studies were included if they investigated the use of OLZ/SAM treatment in patients with schizophrenia or bipolar disorder-I, and reported the clinical outcomes: efficacy, change in weight or waist circumference, tolerability, pharmacokinetics, or change in metabolic parameters.