Bilateral efforts to improve SERS detection efficiency of exosomes by Au/NaPMoO Combined with Phospholipid Epitope Imprinting.

Detection of cancer-related exosomes in body fluids has become a revolutionary strategy for early cancer diagnosis and prognosis prediction. We have developed a two-step targeting detection method, termed PS-MIPs-NELISA SERS, for rapid and highly sensitive exosomes detection. In the first step, a phospholipid polar site imprinting strategy was employed using magnetic PS-MIPs (phospholipids-molecularly imprinted polymers) to selectively isolate and enrich all exosomes from urine samples.

Understanding Metal-Semiconductor Plasmonic Resonance Coupling through Surface-Enhanced Raman Scattering.

Although there has been intense research on plasmon-induced charge transfer within metal/semiconductor heterostructures, previous studies have all focused on the surface plasmonic resonance (SPR) of only noble metals. Herein and for the first time, we observe and take into account the plasmonic coupling between SPR of both noble-metal and semiconductor nanostructures. A WO/Ag heterostructure composed of metallic Ag nanoparticles (Ag NPs) and semiconducting WO nanowires (WO NWs) is designed and fabricated, which exhibits a broad and strong SPR absorption in the visible wavelength range.