Measurement of retinal nerve fiber layer thickness and macular volume for glaucoma detection using optical coherence tomography.

Purpose: To evaluate retinal nerve fiber layer (RNFL) thickness and macular volume in normal eyes and in the eyes of patients with glaucoma, and to compare the usefulness of these measurements in diagnosing glaucomatous eyes.

Methods: Eighty-one eyes were divided into three groups: normal control (n = 31), early glaucoma [n = 31, mean deviation (MD) >or= -6 dB], and advanced glaucoma (n = 19, MD < -6 dB). The RNFL thickness and macular volume were measured using Stratus OCT (optical coherence tomography).

[Visual field defects in high myopic glaucoma compared with moderate myopic glaucoma].

Purpose: To demonstrate the visual field defects characteristic of high myopic glaucoma eyes.

Methods: Eighty-one high myopic glaucoma eyes (< or = -8 diopter(D)) and eighty moderate myopic glaucoma eyes(-3 D approximately -6 D) from patients under the age of 60 were enrolled in this study. Visual acuity, Mean Deviation (MD) of Humphrey visual field analyzer (HFA) central 30-2 program, and the pattern of central visual field defect especially at the early stage of glaucoma (MD > or = -10 dB) were compared between high and moderate myopic groups.

Scanning laser polarimetry with variable corneal compensation and optical coherence tomography in tilted disk.

Purpose: To determine whether scanning laser polarimetry with variable corneal compensation (GDx-VCC) or optical coherence tomography (OCT) is helpful for the analysis of the retinal nerve fiber layer (RNFL) thickness in glaucoma subjects with tilted disk.

Design: Retrospective case-control study.

Methods: We included 21 glaucomatous eyes with tilted disk and 35 glaucomatous eyes without tilted disk.

A rat model of glaucoma induced by episcleral vein ligation.

To establish a reliable animal model of glaucoma, we examined if episcleral vein ligation in rat eyes can induce intraocular pressure (IOP) elevation and concomitant characteristic morphological features of glaucoma. IOP elevation was detected on the next day (30.1+/-4.

Effects of bone marrow stromal cell injection in an experimental glaucoma model.

We investigated if bone marrow stromal cells (BMSCs) transplanted into the vitreous body of a glaucoma model eye could be integrated in the host retina and also whether they could rescue the retinal ganglion cells (RGCs) from death induced by the elevated intraocular pressure. Glaucoma was induced in the right eye of adult Wistar rats by ligating the episcleral veins. The GFP-expressing BMSCs (GFP-BMSCs) were injected into the vitreous body of both the control and the glaucomatous eyes.

Coloration of fundus lesions in bilateral diffuse uveal melanocytic proliferation.

Purpose: To report differences in the coloration of fundus lesions between Asian and Caucasian patients with bilateral diffuse uveal melanocytic proliferation (BDUMP).

Cases: This syndrome was detected in 2 Japanese patients, 69 and 73 years old, with lung cancer who visited our department complaining of visual disturbances. The coloration of the fundus lesions was investigated in these 2 patients.

Vitreous surgery combined with internal limiting membrane peeling for traumatic macular hole with severe retinal folds.

Purpose: To report a case of a traumatic macular hole with severe retinal folds in which vitreous surgery combined with internal limiting membrane (ILM) peeling was beneficial. To demonstrate that the area from which the ILM was peeled can be clearly differentiated by scanning laser ophthalmoscopy.

Methods: A posterior hyaloid detachment was created during vitreous surgery on a 34 year old man with a traumatic macular hole.