Publications by authors named "Saixue Yang"

Fungal infections pose severe and potentially lethal threats to plant, animal, and human health. Ergosterol has served as the primary target for developing antifungal medications. However, many antifungal drugs remain highly toxic to humans due to similarity in cell membrane composition between fungal and animal cells.

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Chronic wounds of significant severity and acute injuries are highly vulnerable to fungal infections, drastically impeding the expected wound healing trajectory. The clinical use of antifungal therapeutic drug is hampered by poor solubility, high toxicity and adverse reactions, thereby necessitating the urgent development of novel antifungal therapy strategy. Herein, this study proposes a new strategy to enhance the bioactivity of small-molecule antifungal drugs based on multifunctional metal nanozyme engineering, using amphotericin B (AmB) as an example.

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Article Synopsis
  • Iturin A, a lipopeptide, shows promise in treating infections caused by a specific fungus, affecting factors such as hypha formation and biofilm development.
  • The study found that iturin A has a minimal inhibitory concentration of 25 µg/mL and outperforms nystatin in reducing fungal growth in a mouse model of oral infection.
  • Iturin A treatment at high doses did not harm the mice's health, indicating its potential for safe use in managing oral fungal infections.
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Metal corrosion caused by Aspergillus sp. was shown to be significantly enhanced on a space station, but its mechanism is still unknown. To simulate this on earth, the corrosion capability of A.

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