Publications by authors named "Saiwei Lu"
The relationship between dietary inflammation index (DII) and the risk of hypertension is inconsistent across published epidemiological studies. This meta-analysis aimed to investigate the dose-response relationship between DII score and the risk of hypertension. A systematic search for relevant studies was conducted in PubMed, Web of Science, and Embase databases until January 9, 2024.
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- Vaccination against enterovirus A71 (EV-A71) has shown over 90% effectiveness in clinical trials, but real-world effectiveness and its epidemiological impact on hand, foot, and mouth disease (HFMD) remain uncertain.
- A study analyzed data from 18 records, revealing that a one-dose EV-A71 vaccine has a 66.9% effectiveness, while a two-dose version increases that efficacy to 84.2%, with mainly mild adverse events reported.
- The two-dose EV-A71 vaccine significantly reduces both the incidence and severity of EV-A71-associated HFMD, suggesting that it should be administered to young children to ensure effective prevention, highlighting the need for a broader multivalent HFMD vaccine.
Background: Catalpol, one of the main bioactive components isolated from , was developed by Suzhou Youseen for the treatment of ischemic stroke; however, preclinical information about its absorption, distribution, metabolism, and excretion (ADME) in animals is inadequate.
Objective: This study aimed to illuminate the pharmacokinetics (PK), mass balance (MB), tissue distribution (TD), and metabolism of catalpol after a single intragastric administration of 30 mg/kg (300 μCi/kg) [H]catalpol in rats.
Methods: Radioactivity in plasma, urine, feces, bile, and tissues was measured by liquid scintillation counting (LSC), and metabolite profiling was characterized by UHPLC-β-ram and UHPLC-Q-Exactive plus MS.