Publications by authors named "Sairam Kumar"
Background Postoperative delirium (POD) is a common and debilitating complication in elderly hip fracture patients, associated with significant clinical and functional consequences. Early identification of risk factors, such as cognitive impairment and vitamin D deficiency, is essential to mitigate its impact. However, preoperative screening practices are often inconsistent.
View Article and Find Full Text PDFThe death of someone close to a child often has a profound and lifelong effect on the child and results in a range of both short- and long-term reactions. Pediatricians, within a patient-centered medical home, are in an excellent position to provide guidance to caregivers and to offer assistance and support to grieving children of all ages and their families. This clinical report offers practical suggestions on how to talk with grieving children to help them better understand what has happened and its implications.
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- Joubert syndrome (JS) is a genetic disorder marked by brain malformations and caused by mutations in various genes, with a specific focus on MKS1 mutations that also relate to Meckel-Gruber syndrome (MKS).
- This study identifies eight unreported MKS1 mutations in individuals with JS and shows that while some individuals have characteristics of MKS, most exhibit JS features without truncating mutations typically associated with MKS.
- Findings reveal that fibroblasts from MKS1-related JS individuals have abnormal cilia in terms of number and length, and altered protein levels, suggesting that disruptions in ciliary function and INPP5E content are critical to the disease mechanism linked to MKS1 mutations.