Publications by authors named "Sairah Sheikh"

Introduction: Survival rates of the childhood cancer patients are improving, however cancer treatments such as chemotherapy may lead to infertility due to loss of the primordial follicle (PMF) reserve. Doxorubicin (DXR) is a gonadotoxic chemotherapy agent commonly used in childhood cancers. Anti-Müllerian Hormone (AMH) has been reported to have a protective effect on the mouse ovarian reserve against DXR .

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Objective: To assess the motivations and perceptions of the general public in the United Kingdom toward donating their uterus for Uterus Transplantation after death (UTx).

Design: A cross sectional study.

Setting: A 32-item electronic questionnaire.

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Article Synopsis
  • The study explores premature ovarian insufficiency (POI) and its unclear mechanisms, using a mouse model to show that oocyte deletion impacts follicle development.
  • Analysis of DM mice at various developmental stages reveals a blockage in follicle progress, with findings indicating that intra-ovarian factors play a crucial role in the onset of POI.
  • Transplanting DM ovaries did not restore normal development, but modifying ovarian somatic cells allowed for some progression, highlighting the importance of oocyte and somatic cell communication in follicle development.
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Follicle development requires complex and coordinated interactions between both the oocyte and its associated somatic cells. In ovarian dysfunction, follicle development may be abnormal due to defective somatic cell function; for example, premature ovarian insufficiency or malignancies. Replacing defective somatic cells, using the reaggregated ovary (RO) technique, may 'rescue' follicle development.

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Article Synopsis
  • Premature ovarian insufficiency (POI) affects 1% of women under 40 and is mainly of unknown origin; a genetic mouse model shows pronounced effects on fertility and ovarian function.
  • In the study, while DM mice initially have accelerated follicle growth, they experience decreased survival and rigidity in their ovaries as they age compared to control mice.
  • Despite these challenges, the research suggests that culturing preantral DM follicles can successfully yield antral follicles, indicating potential for future reproductive therapies.
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The objective was to characterise cervical leukocyte populations and inflammatory mediators associated with term and recurrent spontaneous preterm birth (SPTB) in pregnant women with a history of SPTB. A prospective observational study was undertaken on 120 women with a history of SPTB. A cytobrush was used to sample cells from the cervix at 12-25 weeks' gestation.

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