Publications by authors named "Saira Yasmeen"

Article Synopsis
  • Chemotherapeutic drug delivery faces challenges like short half-lives and poor targeting, which this study addresses using pH-responsive hybrid nanoparticles (NPs) made from benzimidazole-coated mesoporous silica loaded with quercetin.
  • The BCD-QUE-BZMSN formulation shows controlled pH-dependent drug release and high drug entrapment efficiency, with promising properties verified through various analyses (FTIR, EDX, NMR, UV, SEM).
  • Results indicate that this nanovalve system offers significantly greater cytotoxic effects against liver and lung cancer cells compared to quercetin alone, highlighting its potential as an effective cancer treatment carrier.
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Wound healing is a multifaceted and complex process that includes inflammation, hemostasis, remodeling, and granulation. Failures in any link may cause the healing process to be delayed. As a result, wound healing has always been a main research focus across the entire medical field, posing significant challenges and financial burdens.

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Gentamicin sulfate (GEN), a well-known broad-spectrum antibiotic is mostly administered through intramuscular injections and entirely excreted in un-metabolized form through urination from patient's body. Quantitative detection of GEN by direct UV absorption is usually challenging due to lack of chromophores and fluorophores in structure. The current study described the hesperidin coated silver nanoparticles (HSPAgNPs) based novel colorimetric quantitative assay for GEN.

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Background and objective Lipocalin-2 (LCN-2) is an adipokine that plays a protective role in various inflammatory disorders and regulates innate immune response to acute and chronic infections. However, scant information is available regarding the relationship between serum LCN-2 levels and type 2 diabetes mellitus (T2DM) occurring concurrently with chronic hepatic infections. The present study sought to investigate the association of LCN-2 with T2DM patients with hepatic infections.

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Objective: To determine the normal liver, spleen, and renal parameters in adult patients with no comorbidities.

Study Design: Cross-sectional study.

Place And Duration Of Study: Dow Institute of Radiology, Ojha Campus, LEJ Campus, and Al-Mustafa Hospital Karachi, from October 2016 to March 2017.

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The aim of this case-control study was to assess TIMP2 level in subjects with or without metabolic syndrome (MetS) and to associate levels with non-alcoholic fatty liver changes (NAFLD). Thirty-three MetS subjects and 55 controls were recruited. Anthropometric data, lipid and glucose profile, TIMP2 and liver ultrasound was performed.

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