Optimization of intravenous administration of hydroxocobalamin in pediatric emergencies - HYDROX-OPTIMIS study.

Introduction: Procedures to prepare and infuse intravenous drugs are poorly documented.

Objective: To determinate the optimal mode of hydroxocobalamin administration in children in emergency care.

Methods: We identified three modes of administration: (1) connect infusion tubing to the vial, start the infusion and interrupt it when the desired dose has been delivered; (2) remove from the vial the volume corresponding to the excessive dose and connect infusion tubing and (3) extract from the vial the required volume to be delivered and infuse directly.