Outcomes of Standard-Risk Multiple Myeloma Patients Who Undergo Upfront Autologous Hematopoietic Stem Cell Transplantation.

Background: Patients with multiple myeloma without high-risk cytogenetic abnormalities are classified as having standard-risk MM (SRMM), and data focusing on their outcomes after autologous stem-cell transplantation (autoHCT) are limited.

Objective: To evaluate survival outcomes for patients with SRMM receiving autoHCT, and to elucidate factors that impact these outcomes.

Study Design: Single-center retrospective analysis that included consecutive MM patients who received upfront autoHCT between 2013-2021, had available cytogenetic information and had no high-risk chromosomal abnormalities on fluorescence in situ hybridization (FISH), defined as t(4;14), t(14;16), del(17p) or 1q21 gain or amplification.

Outcome of Patients With Central Nervous System Multiple Myeloma (CNS-MM) Treated With CNS-Directed Radiation Therapy.

Background: The prognosis of multiple myeloma involving the central nervous system (CNS-MM) is poor. We report outcomes of CNS-MM treated with CNS-directed radiation therapy (RT).

Methods: We retrospectively reviewed patients with CNS-MM treated with CNS-directed RT from 2015 to 2024.

Multiple DNA repair pathways prevent acetaldehyde-induced mutagenesis in yeast.

Acetaldehyde is the primary metabolite of alcohol and is present in many environmental sources including tobacco smoke. Acetaldehyde is genotoxic, whereby it can form DNA adducts and lead to mutagenesis. Individuals with defects in acetaldehyde clearance pathways have increased susceptibility to alcohol-associated cancers.

Bimetallic PdPt nanoparticle-incorporated PEDOT:PSS/guar gum-blended membranes for enhanced CO separation.

To address the escalating demand for efficient CO separation technologies, we introduce novel membranes utilizing natural polymer guar gum (GG), conjugate polymer (poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate)) PEDOT:PSS, and bimetallic PdPt nanoparticles. Bimetallic PdPt nanoparticles were synthesized using the wet chemical method and characterized using X-ray photoelectron spectroscopy (XPS) and transmission electron microscopy (TEM) techniques. The morphologies, chemical bonds, functional groups, and mechanical properties of the fabricated membranes were characterized using various techniques.

Bimetallic PdPt Nanoparticles Decorated PES Membranes for Enhanced H Separation.

Hydrogen separation has significant importance in diverse applications ranging from clean energy production to gas purification. Membrane technology stands out as a low-cost and efficient method to address the purpose. The development of efficient gas-sensitive materials can further bolster the membrane's performance.

Optimal infused CD34 cell dose in multiple myeloma patients undergoing upfront autologous hematopoietic stem cell transplantation.

Autologous transplantation remains the standard of care for eligible multiple myeloma (MM) patients, yet optimal CD34 cell dose remains unclear. We conducted a retrospective study on MM patients undergoing upfront transplant between 2005 and 2021 and divided them into low (≤2.5 × 10 cells/kg) and high (>2.

Antibiotic-induced loss of gut microbiome metabolic output correlates with clinical responses to CAR T-cell therapy.

Antibiotic-induced microbiome dysbiosis is widespread in oncology, adversely affecting outcomes and side effects of various cancer treatments, including immune checkpoint inhibitors and chimeric antigen receptor T (CAR-T) cell therapies. In this study, we observed that prior exposure to broad-spectrum ABX with extended anaerobic coverage like piperacillin-tazobactam and meropenem was associated with worsened anti-CD19 CAR-T therapy survival outcomes in large B-cell lymphoma patients (n=422), compared to other ABX classes. In a discovery subset of these patients (n=67), we found that the use of these ABX was in turn associated with substantial dysbiosis of gut microbiome function, resulting in significant alterations of the gut and blood metabolome, including microbial effectors such as short-chain fatty acids (SCFAs) and other anionic metabolites, findings that were largely reproduced in an external validation cohort (n=58).

Natural Teeth for Prosthetic Solutions in Pediatric Patients: Two Case Reports of Biologically Based Removable Functional Partial Dentures.

Prosthetic appliances are essential for promoting the proper development of teeth, dental arches, and facial bones in children. Due to the constantly changing nature of a child's oral environment, these appliances must be temporary and require regular maintenance and adjustment to avoid impeding orofacial growth. A fundamental aspect of contemporary dentistry is re-establishing aesthetics.

An Atypical Occurrence of Epidermoid Cyst in the Postauricular Parotid Region of a Young Child: A Case Report and Literature Review.

Benign epidermal cysts, also called epidermoid cysts, can sometimes develop in the orofacial region from trapped epidermal components without skin adnexal appendages. Congenital or acquired conditions could be the case. Epidermoid cysts have been found to occur in 6.

Microstructure Morphology of Chemical and Structural Phase Separation in Thermally Treated KFeSe Superconductor.

The iron-based KFeSe superconductor displays chemical, structural and electronic phase separation at nanoscale to microscale, leading to the coexisting metallic phase embedded in an antiferromagnetic host matrix. The metallic character of the system is believed to arise from a percolative granular network affecting its transport in the normal as well as in the superconducting state. This percolative network can be manipulated and controlled through thermal treatments.

Widespread mutagenesis and chromosomal instability shape somatic genomes in systemic sclerosis.

Systemic sclerosis is a connective tissue disorder characterized by excessive fibrosis that primarily affects women, and can present as a multisystem pathology. Roughly 4-22% of patients with systemic sclerosis develop cancer, which drastically worsens prognosis. However, the mechanisms underlying systemic sclerosis initiation, propagation, and cancer development are poorly understood.

Multidisciplinary Collaboration in Combatting Antimicrobial Resistance: Insights and Outcomes From the National Alliance of Medical Professionals on Antimicrobial Resistance (NAMP-AMR) Initiative.

Antimicrobial resistance (AMR) poses a critical global health challenge, requiring a coordinated and vigorous response. Despite numerous global and national efforts, a unified multidisciplinary approach has been missing. The National Alliance of Medical Professionals on Antimicrobial Resistance (NAMP-AMR), led by the Indian Medical Association in collaboration with key stakeholders such as NITI Aayog and the Ministry of Health, seeks to address this gap.

Aldehyde-induced DNA-protein crosslinks- DNA damage, repair and mutagenesis.

Aldehyde exposure has been shown to lead to the formation of DNA damage comprising of DNA-protein crosslinks (DPCs), base adducts and interstrand or intrastrand crosslinks. DPCs have recently drawn more attention because of recent advances in detection and quantification of these adducts. DPCs are highly deleterious to genome stability and have been shown to block replication forks, leading to wide-spread mutagenesis.

Assessment of Chronic Malnutrition and Its Correlation With Oral Health Status in Children Aged Three to Six Years in Jabalpur District, India: An Epidemiological Study.

Objective: This study aims to examine the correlation of chronic malnutrition with the oral health status of children aged three to six years.

Methods: A total of 400 children were selected and divided into four groups based on z-scores. For evaluation of oral health status, teeth were examined for dental caries using the decayed, missing, and filled permanent teeth (DMFT) scores.

Hereditary Multiple Exostoses with Rare Ocular Finding: A Case Report.

Purpose: To study rare ocular findings in a rare case of hereditary multiple exostoses (HME) and to study HME in one family.

Methods: HME is an autosomal dominant genetic disease characterized by the presence of multiple exostoses (osteochondromas). It is caused by mutations in two genes: exostosin-1 (EXT1) and exostosin-2 (EXT2).

Patient-derived colon epithelial organoids reveal lipid-related metabolic dysfunction in pediatric ulcerative colitis.

Background & Aims: Ulcerative colitis (UC) is associated with epithelial metabolic derangements which exacerbate gut inflammation. Patient-derived organoids recapitulate complexities of the parent tissue in health and disease; however, whether colon organoids (colonoids) model metabolic impairments in the pediatric UC epithelium is unclear. This study determined the functional metabolic differences in the colon epithelia using epithelial colonoids from pediatric patients.

ZIF-67@polyvinylidene fluoride mixed matrix membranes towards improved hydrogen separation performance.

This work is primarily focused on overcoming the limitations of polymeric membranes in achieving the balance between permeability and selectivity of the separation performance. The filler, Zeolitic imidazole framework -67 (ZIF-67) nanoparticles were synthesised in cubical morphology using hexadecyltrimethylammonium bromide (CTAB) as a surfactant via the wet-chemical method. The uniform particles with particle sizes ranging between 120-180 nm were incorporated into the polyvinylidene fluoride (PVDF) matrix to fabricate mixed matrix membranes via the phase inversion method.

Innovative Aesthetic and Functional Rehabilitation in a Two-and-a-Half-Year-Old Using a Modified Groper's Appliance.

The repercussions of the early loss of primary teeth, be it from trauma or caries, encompass compromised chewing efficiency, diminished aesthetics, potential development of abnormal oral habits, and difficulty in articulation of labiodental sounds, significantly influencing the child's psychological well-being and behavior. Moreover, the untimely loss of posterior teeth results in the loss of space, potentially leading to malocclusion and functional disruptions. Hence, addressing dental rehabilitation in these cases is both a challenge and a necessity.

Effectiveness of chitosan nanoparticles, and novel chemical irrigants with surfactant on smear layer removal and microhardness alteration.

Objective: This current study was designed to compare and correlate between smear layer eradication and reduction in microhardness by natural 0.2%chitosan nanoparticles and novel chemical irrigants with surfactant at the apical root third.

Materials And Method: One hundred and twenty straight single-rooted extracted lower premolars were decoronated and working length obtained with #10 K-file.

Effect of aliovalent substitution on the local structure of CaKFeAssuperconductor.

We have investigated the local structure of the iron-based CaKFeAssuperconductor featuring distinct aliovalent substitutions at the Ca and K sites, that is CaKFeAs, CaKSrFeAs, CaKBaFeAsand CaNaKBaFeAs. Temperature-dependent Fe K-edge extended x-ray absorption fine structure (EXAFS) measurements are used to determine the near-neighbors bondlengths and their stiffness. The EXAFS analysis reveals that the Fe-As bondlength undergoes negligible changes by substitution, however, the Fe-Fe bondlength and the As height are affected by the Sr substitution.