Publications by authors named "Sainath Dharmavaram Kottam"
Cu-Catalyzed Tandem C-N and C-C Bond Formation Leading to 4()-Quinolones: A Scaffold with Diverse Biological Properties from Totally New Raw Materials in a Single Step.
Satyanarayana Tummanapalli Kali Charan Gulipalli Srinu Bodige Anil Kumar Pommidi Ravi Boya Sainath Dharmavaram Kottam
J Org Chem
February 2024
Article Synopsis
- - A new Cu-catalyzed method has been developed to create 2-substituted-4-()-quinolones, which are important in medicinal chemistry due to their various biological properties.
- - This one-step reaction uses easily available materials like aryl boronic acid and nitriles, requiring only a cheap copper catalyst and air as an oxidant, making it more environmentally friendly compared to traditional and modern methods.
- - The study also includes the first total synthesis of punarnavine and proposes a mechanism involving the formation of an aryl nitrilium ion followed by a tandem C-C bond formation.
Chromone-2-carboxylate scaffold is growing as an important pharmacophore in medicinal chemistry with diverse biological properties. We have developed a facile one-pot transformation of 2-fluoroacetophenone directly to chromone-2-carboxylate scaffold in a single step via a tandem C-C and C-O bond formation. The majority of the previously reported medicinal chemistry synthetic protocols primarily used only one procedure which follows a two-step strategy that needs to start with "2-hydroxyacetophenone".
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