Recent developments of metal N-heterocyclic carbenes as anticancer agents.

Metal based anticancer drugs have demonstrated their crucial role in preventing all types of cancers whereas their effectiveness is selective with respect to the cancer cells rather than the normal cells. Recently metal N-heterocyclic carbenes have established their selective performance for cancer cells excluding normal healthy cells based on which they are widely utilised for targeting cancer cells specifically which leads to cell death or cell growth inhibition. This is mainly due to their ionic character which helps them to localise in cancer cells with the help of enhanced expression of Organic Cation Transporters (OCT).

Thiazolidinediones : A class of pharmacologically important molecules.

Thiazolidinediones are one of the important chemical class of heterocyclic compounds that can be synthesized from thiourea and chloroacetic acid. Thiazolidinedione ring upon substitution with different scaffolds like benzylidene, methoxynapthalene, ester, benzyl shows wide spectrum of pharmacological activities like antihyperglycemic, anticancer, aldose reductase (ALR) inhibition, anti-inflammatory, PGDH inhibition, Keratin pigmentation, antioxidant and antimicrobial activity. Many drugs are marketed as well as removed amongst thiazolidinediones.