Publications by authors named "Sainan Wan"
Article Synopsis
- The study compared the pharmacokinetics (PK) and pharmacodynamics (PD) of two rapid-acting insulin products: a new biosimilar (RD10046) and NovoRapid, aimed at controlling post-meal blood glucose levels.
- Participants were healthy Chinese males who received both insulin products in a crossover trial, completing all treatment periods without any adverse events like hypoglycemia or allergic reactions.
- Results showed that PK and PD measures were similar for both products, indicating that RD10046 is bioequivalent to NovoRapid, as the 90% confidence intervals met the acceptance criteria.
Acute lung injury (ALI) is a major cause of mortality and morbidity worldwide. In a previous study we reported the synthesis of a series of apocynin derivatives. Although the anti-inflammatory activity of them contributes to these cytoprotective effects.
View Article and Find Full Text PDFWe have designed and synthesized a series of novel apocynin analogues, and evaluated their biological activity. Compound 10, an apocynin dimer analogue, compound 12, the lipoic acid (LA) and apocynin conjugate, were the most potent in protecting cells from lipopolysaccharide (LPS)-induced cytotoxicity, had significant activity scavenging ROS induced by LPS, and greatly decreased LPS-induced P67(phox) protein expression. SAR analysis suggests that modification of apocynin can increase its activity.
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