Bilirubin level is decreased in patients with allergic rhinitis.

Background: There are limitations in detecting methods for early diagnosis and screening of allergic rhinitis. Considering the anti-inflammatory and anti-oxidative effects of bilirubin, this study aims to explore the relationship between bilirubin and allergic rhinitis and to identify bilirubin-related candidate urinary protein biomarkers associated with allergic rhinitis.

Methods: 63 allergic rhinitis patients (AR group) and 86 healthy controls (NC group) were enrolled.

Chlorogenic acid attenuates inflammation in LPS-induced Human gingival fibroblasts via CysLT1R/Nrf2/NLRP3 signaling.

Periodontitis is a chronic periodontal inflammatory disease and its etiology remains not fully understood. Chlorogenic acid (CA) is an ingredient isolated from nature product and exerts anti-inflammatory property. The purpose of the present study was to estimate the effect of CA on LPS-induced Human gingival fibroblasts (HGFs) and explore its mechanism.

MicroRNA-153 functions as a tumor suppressor in gastric cancer via targeting Kruppel-like factor 5.

[This retracts the article DOI: 10.3892/etm.2018.

Fisetin attenuates periodontitis through FGFR1/TLR4/NLRP3 inflammasome pathway.

The purpose of the present study was to investigate the pharmacological effect of Fisetin on experimental periodontitis in rats and explore its potential mechanism. The ligature/LPS method was used to induce periodontitis in rats. LPS was employed to cause inflammation in Human gingival fibroblasts (HGF).

MicroRNA-153 functions as a tumor suppressor in gastric cancer via targeting Kruppel-like factor 5.

Various microRNAs (miRs) have been demonstrated to serve important roles in gastric cancer (GC). miR-153 in particular has been reported to serve a suppressive role in GC; however, the underlying mechanism remains unclear. In the present study Reverse transcription-quantitative polymerase chain reaction and western blot analysis were used to examine the mRNA and protein expression of Kruppel-like factor 5.