Publications by authors named "Saimun Singla"
Background: A better understanding of the pathogenesis of polyarticular juvenile idiopathic arthritis (polyJIA) is needed to aide in the development of data-driven approaches to guide selection between therapeutic options. One inflammatory pathway of interest is JAK-STAT signaling. STAT3 is a transcription factor critical to the differentiation of inflammatory T helper 17 cells (Th17s).
View Article and Find Full Text PDFBackground: Several studies suggest that defects of regulatory T-cells (Tregs) and impaired cellular immunity are secondary to an imbalance between auto-aggressive T-cells and Tregs in lupus patients. Discrepancies in Tregs and effector T-cells (Teff) in active lupus patients are shown to be restored in patients upon receiving immunosuppressive therapy. Therefore, our main aim was to observe frequencies of these CD4 T-cell subsets and Tregs/Teff ratio in a new diagnosis of childhood-onset systemic lupus erythematous (cSLE) before and after initiation of therapy.
View Article and Find Full Text PDFArticle Synopsis
- Diffuse alveolar hemorrhage (DAH) is a serious condition in children with childhood-onset systemic lupus erythematosus (cSLE), characterized by low hematocrit levels, breathing difficulties, and signs of lung damage.
- A study at a pediatric medical center over a decade found that 7 out of 410 children with cSLE experienced DAH, predominantly affecting males and those of Hispanic descent, with an average diagnosis age of 14 years.
- Most patients showed respiratory issues, anemia, and positive autoantibodies, with treatment involving corticosteroids and immunomodulators; 86% survived without recurrence after an average follow-up of 2.5 years.