Publications by authors named "Saima Ghaus"

Objective: To estimate the burden of vitamin D deficiency and its association with chronic diseases in patients visiting a private endocrinology clinic in an urban setting.

Methods: The retrospective study was conducted at the Medicell Institute of Diabetes Endocrinology & Metabolism, Karachi, and comprised medical records of adult patients of either gender between January 2000 and December 2019.Vitamin D status of the patients and its association with various chronic disorders were investigated.

View Article and Find Full Text PDF
Article Synopsis
  • - The study aimed to evaluate the effectiveness of GLP-1 receptor agonists (GLP-1RAs) in managing weight and blood sugar levels in obese Type 2 Diabetes Mellitus (T2DM) patients over two years in Karachi, Pakistan.
  • - Out of 97 initially enrolled patients, 81 attended follow-ups, receiving either Liraglutide, Dulaglutide, or IDegLira, resulting in significant reductions in weight, BMI, and HbA1c levels, with Dulaglutide showing the best glycemic control.
  • - The findings highlighted that GLP-1RAs were generally well-tolerated, with side effects mainly consisting of nausea, and confirmed their
View Article and Find Full Text PDF

Vitamin D-dependent Rickets Type II (VDDR-II) is a rare autosomal recessive disorder caused by a vitamin D receptor gene mutation, leading to end-organ resistance to 1,25-dihydroxyvitamin D 1,25(OH)2D. We aimed to investigate two cases of VDDR-II. Case 1 was of a 14-year old male, presenting with bone pains, bowing of legs, multiple bone deformities, and fractures since childhood.

View Article and Find Full Text PDF

Introduction In the last 45 years, the worldwide rate of obesity has risen by nearly three-folds. Globally, 650 million adults are obese and more than 1.9 billion are overweight.

View Article and Find Full Text PDF

Background & Objective: Sodium glucose co-transporter-2 inhibitors (SGLT 2 inhibitors) are newer anti-hyperglycemic agents, which improve glycemic control independent of insulin secretion with a low risk of hypoglycemia. This study aimed to assess the efficacy of SGLT 2 inhibitors in terms of glycemic control, weight reduction and safety profile in our patients with type 2 Diabetes (T2D).

Methods: This is a prospective analysis, conducted at Medicell Institute of Diabetes, Endocrinology and Metabolism (MIDEM), Karachi Pakistan from January 2018 till July 2019.

View Article and Find Full Text PDF

Objective: We report an unusual case of untreated hypoparathyroidism in which the patient presented with a prolonged QT interval and unusual bleeding after the institution of acute coronary syndrome (ACS) protocol.

Methods: A 53-year-old female presented with sudden pain and diffuse tightness in the abdomen/limbs and profuse sweating for a few hours. Patient was admitted under cardiology services and ACS protocol was instituted.

View Article and Find Full Text PDF