KBTBD8/RRP15 as a potential novel therapeutic target associates with lenvatinib-inhibited progression in hepatocellular carcinoma both in vitro and in vivo.

Introduction: We have previously demonstrated that RRP15 (Ribosomal RNA Processing 15 Homolog) was significantly elevated in hepatocellular carcinoma (HCC) and correlated directly with poor prognosis. RRP15 suppression curtails HCC progression through induction of cellular senescence and apoptosis. However, the impact of RRP15 on the precise therapeutic potential of lenvatinib has remained underexplored.

Optimizing Metasurface-Component Performance by Improving Transmittance and Phase Match of the Nanopillars.

In the propagation phase of a dielectric metasurface, there are two important problems. Firstly, the range of transmittance of the nanopillars for a building metasurface is usually between 60% and 100%, which reduces the metasurface's overall transmittance and affects the uniformity of the transmitted light. Secondly, the realistic phase provided by the nanopillar cannot be matched very well with the theoretical phase at each lattice location.

The Monocyte-to-Lymphocyte Ratio Predicts Acute Kidney Injury After Acute Hemorrhagic Stroke.

Objectives: Acute kidney injury (AKI) is a serious complication of acute hemorrhagic stroke (AHS). Early detection and early treatment are crucial for patients with AKI. We conducted a study to analyze the role of the monocyte-to-lymphocyte ratio (MLR) in predicting the development of AKI after AHS.

Generation of tunable ultra-short pulse sequences in a quasi-discrete spectral supercontinuum by dark solitons.

We explore how to acquire the tunable ultra-short pulse sequences in a quasi-discrete spectral supercontinuum (SC) via the formation of dark solitons in a fiber with two zero dispersion wavelengths (ZDWs). These dark solitons are produced by pumping two pulses in the normal dispersion that are identical but delayed one with respect to the other. Few-cycle pulses with high power as dual pumps experience temporal breakdown, resulting in a nearly-complete conversion of pump energy into two normal dispersion regions to form the ultra-short pulse sequences separated by dark solitons.

Impact of Vitamin D Receptor Gene Polymorphism on Chronic Renal Failure Susceptibility.

Our pooled analysis aimed to assess the impact of vitamin D receptor (VDR) gene polymorphism on chronic renal failure (CRF) susceptibility. Relevant studies were searched from multiple databases, then pooled-analyses were performed using Stata software. Eighteen studies involving 2512 CRF patients and 3630 healthy controls were included.

Harnessing rogue wave for supercontinuum generation in cascaded photonic crystal fiber.

Based on induced modulation instability, we present a numerical study on harnessing rogue wave for supercontinuum generation in cascaded photonic crystal fibers. By selecting optimum modulation frequency, we achieve supercontinuum with a great improvement on spectrum stability when long-pulse is used as the pump. In this case, rogue wave can be obtained in the first segmented photonic crystal fiber with one zero dispersion wavelength in a controllable manner.

Controlled generation of high-intensity optical rogue waves by induced modulation instability.

Optical rogue waves are featured as the generation of high amplitude events at low probability in optical systems. Moreover, the formation of optical rogue waves is unpredictable and transient in photonic crystal fibers. In this paper, we put forward a method to generate high-intensity optical rogue waves in a more controlled way based on induced modulation instability, which can suppress the noise effect and hence play a leading role in the process of pulse evolution.