Publications by authors named "Sailesh Karki"
Article Synopsis
- A case study discusses a 22-year-old woman diagnosed with pulmonary tuberculosis (TB) who also tested positive for non-tuberculous mycobacteria (NTM) after four months of TB treatment.
- The patient's chest imaging showed scarring in the lungs, and following intensive TB treatment, she had to be referred to an infectious disease specialist due to an allergy to azithromycin, impacting her treatment options.
- The coexistence of NTM raises important considerations in treatment, including differentiating between colonization and active disease, as well as addressing the risks of long treatment durations, drug toxicity, and costs.
Article Synopsis
- Malaria and thrombotic thrombocytopenic purpura (TTP) can show similar symptoms, complicating diagnosis.
- A 55-year-old woman with a history of travel to Nigeria exhibited symptoms like abdominal pain and fever, alongside lab results indicating low hemoglobin and platelets.
- Despite initial suspicion for TTP due to similar lab findings and confusion, treatment with artemether-lumefantrine for malaria led to significant improvement, highlighting the importance of understanding the similarities in thrombocytopenic conditions for accurate diagnosis and treatment.
Acute painful vaso-occlusive crisis (VOC) is the common presentation of sickle cell disease (SCD) leading to emergency room visits, admissions, morbidity, mortality, and negative impacts on quality of life. Among various treatment approaches commonly employed to manage the condition, intravenous (IV) hydration is also frequently used in emergency and inpatient settings. Although helpful to overcome dehydration, IV hydration often leads to adverse outcomes like fluid overload, pulmonary edema, increased length of stay, transfer to intensive care unit, new oxygen requirement, etc.
View Article and Find Full Text PDFCefepime, a commonly prescribed fourth-generation cephalosporin, is well-known for its broad-spectrum antibacterial activity. While adverse drug reactions associated with cefepime are well documented, thrombocytopenia as a rare complication has gained attention due to its potential severity. Symptomatic patients present with purpura (bruising), petechiae (small red or purple spots on the skin), and mucosal bleeding.
View Article and Find Full Text PDFHeparin-induced thrombocytopenia (HIT) is categorized into type 1 and type 2. It causes a decrease in platelet count during or shortly after exposure to heparin. Type 1 is mild and has a non-immune mechanism.
View Article and Find Full Text PDFColorectal carcinoma has increasingly been reported to be associated with gut microbial dysbiosis. , , , , etc., are gut microbes commonly associated with colorectal carcinoma.
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