Publications by authors named "Sailaja Nakka"
Article Synopsis
- Human serum albumin (HSA) is crucial for drug transport, and this study investigates the cytotoxic effects of 7-hydroxycoumarin derivatives on mouse macrophage cells.
- The derivatives showed concentration-dependent growth inhibition in inflamed macrophages, with varying IC50 values and notable binding affinity to HSA, confirmed through fluorescence and molecular dynamics methods.
- The interaction with HSA causes structural changes in the protein, indicating specific binding to certain subdomains, while having minimal interaction with another protein, α-1-glycoprotein.
